Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells through a ROS-dependent mechanism. - Wikidata - awgldk - TriplyDB

Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells through a ROS-dependent mechanism.

Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells through a ROS-dependent mechanism.

http://www.wikidata.org/entity/Q33654935

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Preclinical evidences toward the use of triterpenoid CDDO-Me for solid cancer prevention and treatment Pristimerin Induces Apoptosis in Prostate Cancer Cells by Down-regulating Bcl-2 through ROS-dependent Ubiquitin-proteasomal Degradation Pathway Novel phosphorylation and ubiquitination sites regulate reactive oxygen species-dependent degradation of anti-apoptotic c-FLIP protein Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a.Radiation protection of the gastrointestinal tract and growth inhibition of prostate cancer xenografts by a single compound.Apoptotic and autophagic effects of Sesbania grandiflora flowers in human leukemic cells.The effect of ex vivo CDDO-Me activation on nuclear factor erythroid 2-related factor 2 pathway in white blood cells from patients with septic shock.Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells.Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.Antiproliferative and Apoptosis Inducing Effects of Non-Polar Fractions from Lawsonia inermis L. in Cervical (HeLa) Cancer Cells.Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.Oxidative Stress Attenuates Lipid Synthesis and Increases Mitochondrial Fatty Acid Oxidation in Hepatoma Cells Infected with Hepatitis C Virus.Protective effects of ginsenoside Rg2 against H2O2-induced injury and apoptosis in H9c2 cells.Inhibition of telomerase activity by oleanane triterpenoid CDDO-Me in pancreatic cancer cells is ROS-dependent.ROS mediate proapoptotic and antisurvival activity of oleanane triterpenoid CDDO-Me in ovarian cancer cells Synthetic oleanane triterpenoid, CDDO-Me, induces apoptosis in ovarian cancer cells by inhibiting prosurvival AKT/NF-κB/mTOR signaling.Targeting nrf2-mediated gene transcription by triterpenoids and their derivatives.The Synthetic Triterpenoid RTA 405 (CDDO-EA) Halts Progression of Liver Fibrosis and Reduces Hepatocellular Carcinoma Size Resulting in Increased Survival in an Experimental Model of Chronic Liver Injury.Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: preclinical and clinical evidence.Genetic determinants of oxidative stress-mediated sensitization of drug-resistant cancer cells.Current evidence on the anticancer potential of Chios mastic gum.Triterpenoid Acids as Important Antiproliferative Constituents of European Elderberry Fruits.Increased Intracellular Reactive Oxygen Species Mediates the Anti-Cancer Effects of WZ35 via Activating Mitochondrial Apoptosis Pathway in Prostate Cancer Cells.SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells.Antioxidant enzyme inhibitor role of phosphine metal complexes in lung and leukemia cell lines.Synthesis and evaluation of the anticancer activity of albiziabioside A and its analogues as apoptosis inducers against human melanoma cells.Cytotoxic and apoptosis-inducing activities, and anti-tumor-promoting effects of cyanogenated and oxygenated triterpenes.Lantabetulic acid derivatives induce G1 arrest and apoptosis in human prostate cancer cells.Pretreatment of SH-SY5Y cells with dicaffeoylquinic acids attenuates the reduced expression of nicotinic receptors, elevated level of oxidative stress and enhanced apoptosis caused by β-amyloid peptide.Icariin synergizes with arsenic trioxide to suppress human hepatocellular carcinoma.A new development of triterpene acid-containing extracts from Viscum album L. displays synergistic induction of apoptosis in acute lymphoblastic leukaemia.Synthetic triterpenoid CDDO derivatives modulate cytoprotective or immunological properties in astrocytes, neurons, and microglia.Oleanolic acid inhibits cell survival and proliferation of prostate cancer cells in vitro and in vivo through the PI3K/Akt pathway.Combining the FLT3 inhibitor PKC412 and the triterpenoid CDDO-Me synergistically induces apoptosis in acute myeloid leukemia with the internal tandem duplication mutation Betulinic acid induces apoptosis by regulating PI3K/Akt signaling and mitochondrial pathways in human cervical cancer cells.Inhibitory Activities of Butanol Fraction from Butea monosperma (Lam.) Taub. Bark Against Free Radicals, Genotoxins and Cancer Cells.Rosbin, a synthetic small molecule, induces A549 cells apoptosis through a ROS-mediated pathway.Combined targeting of STAT3 and STAT5: a novel approach to overcome drug resistance in chronic myeloid leukemia.Pseudo-Ginsenoside Rh2 induces A549 cells apoptosis via the Ras/Raf/ERK/p53 pathway.FPOA induces apoptosis in HeLa human cervical cancer cells through a caspase-mediated pathway.

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Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells through a ROS-dependent mechanism.

http://www.wikidata.org/entity/Q33654935

description

2009 nî lūn-bûn

@nan

2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年学术文章

@wuu

2009年学术文章

@zh-cn

2009年学术文章

@zh-hans

2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

@yue

name

Oleanane triterpenoid CDDO-Me ...... ugh a ROS-dependent mechanism.

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Oleanane triterpenoid CDDO-Me ...... ugh a ROS-dependent mechanism.

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type

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Oleanane triterpenoid CDDO-Me ...... ugh a ROS-dependent mechanism.

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Oleanane triterpenoid CDDO-Me ...... ugh a ROS-dependent mechanism.

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Oleanane triterpenoid CDDO-Me ...... ugh a ROS-dependent mechanism.

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Oleanane triterpenoid CDDO-Me ...... ugh a ROS-dependent mechanism.

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J.BCP.2009.09.006

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Biochemical Pharmacology

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Oleanane triterpenoid CDDO-Me ...... ugh a ROS-dependent mechanism.

@en

P2093

Ali S Arbab

http://www.w3.org/2001/XMLSchema#string

Branislava Janic

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Dorrah Deeb

http://www.w3.org/2001/XMLSchema#string

Hao Jiang

http://www.w3.org/2001/XMLSchema#string

Scott A Dulchavsky

http://www.w3.org/2001/XMLSchema#string

Subhash C Gautam

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Xiaohua Gao

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P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

The TOR pathway: a target for cancer therapy

NF-kappaB in cancer: from innocent bystander to major culprit

The transcription factor NF-kappaB: control of oncogenesis and cancer therapy resistance.

Cellular response to oxidative stress: signaling for suicide and survival.

Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress

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350-360

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10.1016/J.BCP.2009.09.006

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3

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79

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Yon Rojanasakul

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26838898

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19782051

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apoptotic process

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2822351

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