Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23
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High levels of Hsp90 cochaperone p23 promote tumor progression and poor prognosis in breast cancer by increasing lymph node metastases and drug resistanceProtein homeostasis as a therapeutic target for diseases of protein conformationAlteration of the proteostasis network of plant cells promotes the post-endoplasmic reticulum trafficking of recombinant mutant (L444P) human β-glucocerebrosidase.Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells.Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise.Celastrol stimulates hypoxia-inducible factor-1 activity in tumor cells by initiating the ROS/Akt/p70S6K signaling pathway and enhancing hypoxia-inducible factor-1α protein synthesis.Celastrol regulates multiple nuclear transcription factors belonging to HSP90's clients in a dose- and cell type-dependent way.AFM studied the effect of celastrol on β1 integrin-mediated HUVEC adhesion and migration.Bioactive metabolites from Chaetomium aureum: structure elucidation and inhibition of the Hsp90 machine chaperoning activity.Celastrol protects ischaemic myocardium through a heat shock response with up-regulation of haeme oxygenase-1.Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor.Remarkable stereospecific conjugate additions to the Hsp90 inhibitor celastrolDegradable polyethylenimine derivate coupled to a bifunctional peptide R13 as a new gene-delivery vectorCelastrol analogues as inducers of the heat shock response. Design and synthesis of affinity probes for the identification of protein targetsSuppression of autoimmune arthritis by Celastrus-derived Celastrol through modulation of pro-inflammatory chemokinesGedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis.Heat Shock Protein (HSP) Drug Discovery and Development: Targeting Heat Shock Proteins in Disease.The Hsp90 Co-chaperones Sti1, Aha1, and P23 Regulate Adaptive Responses to Antifungal Azoles.Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer.Targeting Hsp90 and its co-chaperones to treat Alzheimer's diseaseHSP90AB1: Helping the good and the bad.Hsp90 activator Aha1 drives production of pathological tau aggregates.Anticancer Inhibitors of Hsp90 Function: Beyond the Usual Suspects.Mechanisms of Resistance to Hsp90 Inhibitor Drugs: A Complex Mosaic Emerges.Alternative approaches to Hsp90 modulation for the treatment of cancer.Celastrol: A Spectrum of Treatment Opportunities in Chronic DiseasesDiscovery and biological activity of 6BrCaQ as an inhibitor of the Hsp90 protein folding machinery.Disruption of Heat Shock Protein 90 (Hsp90)-Protein Kinase Cδ (PKCδ) Interaction by (-)-Maackiain Suppresses Histamine H1 Receptor Gene Transcription in HeLa Cells.Competitive profiling of celastrol targets in human cervical cancer HeLa cells via quantitative chemical proteomics.
P2860
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P2860
Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Celastrol inhibits Hsp90 chape ...... zation of the Co-chaperone p23
@ast
Celastrol inhibits Hsp90 chape ...... zation of the Co-chaperone p23
@en
type
label
Celastrol inhibits Hsp90 chape ...... zation of the Co-chaperone p23
@ast
Celastrol inhibits Hsp90 chape ...... zation of the Co-chaperone p23
@en
prefLabel
Celastrol inhibits Hsp90 chape ...... zation of the Co-chaperone p23
@ast
Celastrol inhibits Hsp90 chape ...... zation of the Co-chaperone p23
@en
P2093
P2860
P356
P1476
Celastrol inhibits Hsp90 chape ...... zation of the Co-chaperone p23
@en
P2093
Abdul Fauq
Ahmed Chadli
Georges Mer
Maria Victoria Botuyan
Marina Ramirez-Alvarado
Sara J Felts
William P Sullivan
P2860
P304
P356
10.1074/JBC.M109.081018
P407
P577
2009-12-08T00:00:00Z