Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.
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miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stressPIK3CA and AKT1 mutations have distinct effects on sensitivity to targeted pathway inhibitors in an isogenic luminal breast cancer model system.PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα InhibitionThe Coronary Artery Disease-associated Coding Variant in Zinc Finger C3HC-type Containing 1 (ZC3HC1) Affects Cell Cycle RegulationDNA sequence profiles of the colorectal cancer critical gene set KRAS-BRAF-PIK3CA-PTEN-TP53 related to age at disease onset.WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear β-Catenin depend on active PI3K signaling.Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer.HMGA1 induces intestinal polyposis in transgenic mice and drives tumor progression and stem cell properties in colon cancer cellsIKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformationMiR-194 deregulation contributes to colorectal carcinogenesis via targeting AKT2 pathway.Selective anti-cancer agents as anti-aging drugsPI3Kα inhibitors that inhibit metastasis.Protein pathway activation mapping of colorectal metastatic progression reveals metastasis-specific network alterationsA mechanism for asymmetric cell division resulting in proliferative asynchronicity.A kinase-independent function of AKT promotes cancer cell survival.Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis.4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors.Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation.Transcriptional modulator ZBED6 affects cell cycle and growth of human colorectal cancer cells.AKT Inhibition Promotes Nonautonomous Cancer Cell SurvivalRecent discoveries in the cycling, growing and aging of the p53 fieldAspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cellsCell survival and metastasis regulation by Akt signaling in colorectal cancereIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants.Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.AAV-mediated gene targeting methods for human cellsA nanoparticle formulation that selectively transfects metastatic tumors in miceMolecular mechanisms of tumor resistance to PI3K-mTOR-targeted therapy.AKT activation controls cell survival in response to HDAC6 inhibition.Site-specific activation of AKT protects cells from death induced by glucose deprivation.Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules.Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer.GABARAPL1 suppresses metastasis by counteracting PI3K/Akt pathway in prostate cancer.Regulation of glycogen synthase kinase-3 by thymosin beta-4 is associated with gastric cancer cell migration.BMX acts downstream of PI3K to promote colorectal cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737.The influence of AKT isoforms on radiation sensitivity and DNA repair in colon cancer cell lines.YAP/TAZ-Mediated Upregulation of GAB2 Leads to Increased Sensitivity to Growth Factor-Induced Activation of the PI3K Pathway.Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells.The DEAD box protein p68: a crucial regulator of AKT/FOXO3a signaling axis in oncogenesis.Knockdown of Akt2 expression by shRNA inhibits proliferation, enhances apoptosis, and increases chemosensitivity to paclitaxel in human colorectal cancer cells.
P2860
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P2860
Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Genetic inactivation of AKT1, ...... es in tumor growth regulation.
@ast
Genetic inactivation of AKT1, ...... es in tumor growth regulation.
@en
type
label
Genetic inactivation of AKT1, ...... es in tumor growth regulation.
@ast
Genetic inactivation of AKT1, ...... es in tumor growth regulation.
@en
prefLabel
Genetic inactivation of AKT1, ...... es in tumor growth regulation.
@ast
Genetic inactivation of AKT1, ...... es in tumor growth regulation.
@en
P2093
P2860
P4510
P50
P356
P1476
Genetic inactivation of AKT1, ...... es in tumor growth regulation.
@en
P2093
Carlo Rago
Christine Gan
David L Huso
Ian Cheong
Kajsa Ericson
Nickolas Papadopoulos
P2860
P304
P356
10.1073/PNAS.0914018107
P407
P577
2010-01-20T00:00:00Z