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Chemoenzymatic design of heparan sulfate oligosaccharides

Chemoenzymatic design of heparan sulfate oligosaccharides

http://www.wikidata.org/entity/Q33668533

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Glycosaminoglycans and glycomimetics in the central nervous system Biological findings from the recent NMR-based studies of glycosaminoglycan-protein interactions Masquerading microbial pathogens: capsular polysaccharides mimic host-tissue molecules Chemoenzymatic synthesis of heparan sulfate and heparin Engineering of routes to heparin and related polysaccharides Can we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?Using simple donors to drive the equilibria of glycosyltransferase-catalyzed reactions Chemoenzymatic synthesis of heparin oligosaccharides with both anti-factor Xa and anti-factor IIa activities.Molecular mechanism of substrate specificity for heparan sulfate 2-O-sulfotransferase.Chemoenzymatic synthesis and structural characterization of 2-O-sulfated glucuronic acid-containing heparan sulfate hexasaccharides The Good the Bad and the Ugly of Glycosaminoglycans in Tissue Engineering Applications Chemoenzymatic synthesis of homogeneous ultralow molecular weight heparins Chemoenzymatic synthesis of glycosaminoglycans: re-creating, re-modeling and re-designing nature's longest or most complex carbohydrate chains.Synthesis of a targeted library of heparan sulfate hexa- to dodecasaccharides as inhibitors of β-secretase: potential therapeutics for Alzheimer's disease.The dominating role of N-deacetylase/N-sulfotransferase 1 in forming domain structures in heparan sulfate Comamonas testosteronan synthase, a bifunctional glycosyltransferase that produces a unique heparosan polysaccharide analog.Enzymatic placement of 6-O-sulfo groups in heparan sulfate Homogeneous low-molecular-weight heparins with reversible anticoagulant activity.Structural characterization of heparins from different commercial sources Directing the biological activities of heparan sulfate oligosaccharides using a chemoenzymatic approach Chemoenzymatic synthesis of uridine diphosphate-GlcNAc and uridine diphosphate-GalNAc analogs for the preparation of unnatural glycosaminoglycans Structure/function analysis of Pasteurella multocida heparosan synthases: toward defining enzyme specificity and engineering novel catalysts.Role of Deacetylase Activity of N-Deacetylase/N-Sulfotransferase 1 in Forming N-Sulfated Domain in Heparan Sulfate Heparin and related polysaccharides: synthesis using recombinant enzymes and metabolic engineering.Probing structural selectivity of synthetic heparin binding to Stabilin protein receptors Uncovering biphasic catalytic mode of C5-epimerase in heparan sulfate biosynthesis Heparan Sulfate Domains Required for Fibroblast Growth Factor 1 and 2 Signaling through Fibroblast Growth Factor Receptor 1c.Deciphering mode of action of heparanase using structurally defined oligosaccharides.Toward a bioengineered heparin: challenges and strategies for metabolic engineering of mammalian cells Divergent Synthesis of Heparan Sulfate Oligosaccharides.Investigation of the substrate specificity of K5 lyase A from K5A bacteriophage Bioengineered heparins and heparan sulfates.Structurally informative tandem mass spectrometry of highly sulfated natural and chemoenzymatically synthesized heparin and heparan sulfate glycosaminoglycans Preparation and application of a 'clickable' acceptor for enzymatic synthesis of heparin oligosaccharides Strategies in synthesis of heparin/heparan sulfate oligosaccharides: 2000-present.The design and synthesis of new synthetic low-molecular-weight heparins.An approach for separation and complete structural sequencing of heparin/heparan sulfate-like oligosaccharides.Harnessing glycomics technologies: integrating structure with function for glycan characterization.Perspectives on Anti-Glycan Antibodies Gleaned from Development of a Community Resource Database Fibroblast growth factor-based signaling through synthetic heparan sulfate blocks copolymers studied using high cell density three-dimensional cell printing

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Chemoenzymatic design of heparan sulfate oligosaccharides

http://www.wikidata.org/entity/Q33668533

description

2010 nî lūn-bûn

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2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Chemoenzymatic design of heparan sulfate oligosaccharides

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Chemoenzymatic design of heparan sulfate oligosaccharides

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Chemoenzymatic design of heparan sulfate oligosaccharides

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Chemoenzymatic design of heparan sulfate oligosaccharides

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Chemoenzymatic design of heparan sulfate oligosaccharides

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JBC.M110.159152

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Journal of Biological Chemistry

P1476

Chemoenzymatic design of heparan sulfate oligosaccharides

@en

P2093

Arlene S Bridges

http://www.w3.org/2001/XMLSchema#string

Jian Liu

http://www.w3.org/2001/XMLSchema#string

Miao Chen

http://www.w3.org/2001/XMLSchema#string

Michel Weïwer

http://www.w3.org/2001/XMLSchema#string

Paul L DeAngelis

http://www.w3.org/2001/XMLSchema#string

Qisheng Zhang

http://www.w3.org/2001/XMLSchema#string

Renpeng Liu

http://www.w3.org/2001/XMLSchema#string

Xianxuan Zhou

http://www.w3.org/2001/XMLSchema#string

Yongmei Xu

http://www.w3.org/2001/XMLSchema#string

P2860

Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities

Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1

Crystal structure of the sulfotransferase domain of human heparan sulfate N-deacetylase/ N-sulfotransferase 1

Engineering sulfotransferases to modify heparan sulfate

Order out of chaos: assembly of ligand binding sites in heparan sulfate

Sequencing complex polysaccharides.

Modular synthesis of heparan sulfate oligosaccharides for structure-activity relationship studies.

Using an enzymatic combinatorial approach to identify anticoagulant heparan sulfate structures.

A synthetic antithrombin III binding pentasaccharide is now a drug! What comes next?

HABA-based ionic liquid matrices for UV-MALDI-MS analysis of heparin and heparan sulfate oligosaccharides.

P304

34240-34249

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scholarly article

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10.1074/JBC.M110.159152

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P407

P433

44

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285

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Robert J. Linhardt

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2010-08-21T00:00:00Z

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20729556

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oligosaccharide

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2962522

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