The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3
about
TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradationIRF7: activation, regulation, modification and functionISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral responseTRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunityTRIM family proteins and their emerging roles in innate immunityUbiquitin in the activation and attenuation of innate antiviral immunityInterferons in Sjögren's Syndrome: Genes, Mechanisms, and EffectsType I interferon programs innate myeloid dynamics and gene expression in the virally infected nervous systemInhibition of IRF3-dependent antiviral responses by cellular and viral proteins.Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machineryThe E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNATRIM35 negatively regulates TLR7- and TLR9-mediated type I interferon production by targeting IRF7Interaction between innate immunity and Ro52-induced antibody causes Sjögren's syndrome-like disorder in mice.Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblastsSelf protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors.T-helper 17 cell cytokines and interferon type I: partners in crime in systemic lupus erythematosus?Extraordinary antigenicity of the human Ro52 autoantigen.Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases.TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinasesOrigin and evolution of TRIM proteins: new insights from the complete TRIM repertoire of zebrafish and pufferfishThe sequestosome 1/p62 attenuates cytokine gene expression in activated macrophages by inhibiting IFN regulatory factor 8 and TNF receptor-associated factor 6/NF-kappaB activity.Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity.TRIM38 negatively regulates TLR3-mediated IFN-β signaling by targeting TRIF for degradation.The ubiquitin E3 ligase RAUL negatively regulates type i interferon through ubiquitination of the transcription factors IRF7 and IRF3.RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling.Peroxisome proliferator-activated receptor gamma negatively regulates IFN-beta production in Toll-like receptor (TLR) 3- and TLR4-stimulated macrophages by preventing interferon regulatory factor 3 binding to the IFN-beta promoter.The cellular protein La functions in enhancement of virus release through lipid rafts facilitated by murine leukemia virus glycosylated Gag.Fas-associated death domain (FADD) and the E3 ubiquitin-protein ligase TRIM21 interact to negatively regulate virus-induced interferon productionTRIM11 negatively regulates IFNβ production and antiviral activity by targeting TBK1Genetics of transfusion recipient alloimmunization: can clues from susceptibility to autoimmunity pave the way?Vicious circle: systemic autoreactivity in Ro52/TRIM21-deficient miceTRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infectionThe pestivirus N terminal protease N(pro) redistributes to mitochondria and peroxisomes suggesting new sites for regulation of IRF3 by N(pro.).TRIM26 negatively regulates interferon-β production and antiviral response through polyubiquitination and degradation of nuclear IRF3TRIM68 negatively regulates IFN-β production by degrading TRK fused gene, a novel driver of IFN-β downstream of anti-viral detection systemsTRIpartite motif 21 (TRIM21) differentially regulates the stability of interferon regulatory factor 5 (IRF5) isoforms.Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradationAnti-Ro52 autoantibodies from patients with Sjögren's syndrome inhibit the Ro52 E3 ligase activity by blocking the E3/E2 interface.Tripartite motif-containing protein 28 is a small ubiquitin-related modifier E3 ligase and negative regulator of IFN regulatory factor 7.Arterivirus and nairovirus ovarian tumor domain-containing Deubiquitinases target activated RIG-I to control innate immune signaling.
P2860
Q24294243-E106F690-E054-467F-A319-8C22899AD35AQ24299740-5221781B-2626-4F0A-93A4-F4549E470E67Q24322120-1C730855-73D5-4B73-B3F1-AC961B1B5A3BQ24338801-7D81BF2B-AA9C-4FE3-BD95-B1A3E78EFB85Q24607229-257D2BA1-9FFB-44D7-90CB-9E4CB2335CE5Q26771789-94580B4F-ADBC-4789-8727-0668C57D3113Q26865427-D5AADF61-5AE2-47D9-AEB6-884ED86E8CBFQ27334626-FE5384B4-89B6-4769-A5BD-5C3DCB2783A3Q27865225-420C3EDA-9A2D-4463-B035-4D2CBF6CF9DCQ28475642-305AF666-71E2-4EBE-892D-F76633922ED5Q28507251-B5B0AE7D-3D7D-4133-BD88-844ED953C4B8Q28588234-8F85BD1E-A2D0-4B8D-B740-4C24399A6F82Q30300132-BEE64C9E-7805-46B8-BCDE-CA4782B9DCCFQ33579495-CE52EE2E-0D8F-4DF6-B60C-A450BF8ECA3BQ33644464-DEFF749A-E011-447C-9034-3B23AC587749Q33765598-0B6C7121-9404-4D11-A877-C22B463360EAQ33793461-9FFD8736-6D71-4FEC-9347-93FDE3C6524FQ33826676-9574D7CF-FCA5-4574-82BA-D9216E65704EQ33832484-3755960E-CBC0-4C7D-AABC-3EA6CCBD3FFCQ33971228-00F3C147-E27F-4420-A534-686B69B1DDF0Q34118232-18FE7807-8068-4F77-BE7B-CB97F151714EQ34221972-371C4512-B49E-4576-970C-7ED364024F4CQ34442208-6AB4C861-96A8-4E4B-8305-D395BC16FBB5Q34449547-1EDBE284-AC8E-4F09-8FE6-0AF8F61A0DEFQ34545358-7C9536A1-C0C8-4BB2-B800-329E8D241845Q34568504-DAD77CBF-4D22-4115-B9A0-F3CF6AC29EDBQ34591671-A30EF92A-4312-4D6F-95D3-E17B26DA1515Q34675854-4D407302-BC4C-4C82-A50D-F6B19228464EQ34722791-16EC13EA-62D9-459B-8BF0-9FF49CAE3E83Q34792059-73FD7A0B-A04F-4BE2-8A6F-5B93A8710A8CQ34994387-7B9D58E6-6B9D-47B6-9D3B-02B55F41E6ABQ35076566-CA5CB0FE-F32F-40B6-87C2-E0EA0170E069Q35097600-4B0D0EAA-6967-44AB-BC09-D155ACA7E913Q35170790-0A800C02-F737-4D2D-90DC-D8DB2E31FEF6Q35202274-07D12FF2-0752-464A-A78F-A9E58D807060Q35217245-32283EE4-EDDC-4512-A80C-4A0B40970EA7Q35311960-5F3AB992-61F1-4BE3-A1EA-38ED841ECD5AQ35378702-B20B9A06-A572-4807-8670-4DE29B07E1D4Q35402128-E4BDD5AF-81E6-4316-9803-1F319B261192Q35665780-80A82E9D-D87E-49AE-9E8B-5FEC28E1D584
P2860
The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The E3 ubiquitin ligase Ro52 n ...... n-mediated degradation of IRF3
@ast
The E3 ubiquitin ligase Ro52 n ...... n-mediated degradation of IRF3
@en
type
label
The E3 ubiquitin ligase Ro52 n ...... n-mediated degradation of IRF3
@ast
The E3 ubiquitin ligase Ro52 n ...... n-mediated degradation of IRF3
@en
prefLabel
The E3 ubiquitin ligase Ro52 n ...... n-mediated degradation of IRF3
@ast
The E3 ubiquitin ligase Ro52 n ...... n-mediated degradation of IRF3
@en
P2093
P2860
P1476
The E3 ubiquitin ligase Ro52 n ...... n-mediated degradation of IRF3
@en
P2093
Caroline A Jefferies
Eamon P Breen
Joan Ní Gabhann
Katherine A Fitzgerald
Nadia Ben Larbi
Rowan Higgs
P2860
P304
P356
10.4049/JIMMUNOL.181.3.1780
P407
P577
2008-08-01T00:00:00Z