Conformational aspects of inhibitor design: enzyme-substrate interactions in the transition state.
about
Beyond picomolar affinities: quantitative aspects of noncovalent and covalent binding of drugs to proteinsAnatomy of a proficient enzyme: The structure of orotidine 5'-monophosphate decarboxylase in the presence and absence of a potential transition state analogNovel alpha- and beta-amino acid inhibitors of influenza virus neuraminidaseProbing ligand-binding pockets of the mevalonate pathway enzymes from Streptococcus pneumoniae.Crystal structure of HIV-1 protease in situ product complex and observation of a low-barrier hydrogen bond between catalytic aspartatesElaboration of a fragment library hit produces potent and selective aspartate semialdehyde dehydrogenase inhibitors.Stereocontrolled Synthesis of a Potential Transition-State Inhibitor of the Salicylate Synthase MbtI from Mycobacterium tuberculosis.Transition-state variation in human, bovine, and Plasmodium falciparum adenosine deaminases.Distortional binding of transition state analogs to human purine nucleoside phosphorylase probed by magic angle spinning solid-state NMR.Transition States, analogues, and drug development.Substrate Activity Screening (SAS) and Related Approaches in Medicinal Chemistry.Synthesis of imidazole-containing analogues of farnesyl pyrophosphate and evaluation of their biological activity on protein farnesyltransferase.Targeting enzyme inhibitors in drug discovery.Observation of a tetrahedral reaction intermediate in the HIV-1 protease-substrate complex.Immucillins in Infectious Diseases.Limiting Assumptions in the Design of Peptidomimetics.Biochemistry students' ideas about how an enzyme interacts with a substrate.Exploring the divalent effect in fucosidase inhibition with stereoisomeric pyrrolidine dimers.Biochemistry students' ideas about shape and charge in enzyme-substrate interactions
P2860
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P2860
Conformational aspects of inhibitor design: enzyme-substrate interactions in the transition state.
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Conformational aspects of inhi ...... tions in the transition state.
@ast
Conformational aspects of inhi ...... tions in the transition state.
@en
type
label
Conformational aspects of inhi ...... tions in the transition state.
@ast
Conformational aspects of inhi ...... tions in the transition state.
@en
prefLabel
Conformational aspects of inhi ...... tions in the transition state.
@ast
Conformational aspects of inhi ...... tions in the transition state.
@en
P1476
Conformational aspects of inhi ...... tions in the transition state.
@en
P2093
Wolfenden R
P304
P356
10.1016/S0968-0896(98)00247-8
P407
P577
1999-05-01T00:00:00Z