Chemical modification with high molecular weight polyethylene glycol reduces transduction of hepatocytes and increases efficacy of intravenously delivered oncolytic adenovirus - Wikidata - awgldk - TriplyDB

Chemical modification with high molecular weight polyethylene glycol reduces transduction of hepatocytes and increases efficacy of intravenously delivered oncolytic adenovirus

Chemical modification with high molecular weight polyethylene glycol reduces transduction of hepatocytes and increases efficacy of intravenously delivered oncolytic adenovirus

http://www.wikidata.org/entity/Q33690982

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New viruses for cancer therapy: meeting clinical needs PEGylated Adenoviruses: From Mice to Monkeys Oncolytic Adenovirus: Strategies and Insights for Vector Design and Immuno-Oncolytic Applications Development of Novel Adenoviral Vectors to Overcome Challenges Observed With HAdV-5-based Constructs Trial Watch:: Oncolytic viruses for cancer therapy Enhanced tumor uptake and penetration of virotherapy using polymer stealthing and focused ultrasound Expanded anticancer therapeutic window of hexon-modified oncolytic adenovirus.Current issues and future directions of oncolytic adenoviruses.Oncolytic Viruses for Cancer Therapy: Overcoming the Obstacles.Modifications of adenovirus hexon allow for either hepatocyte detargeting or targeting with potential evasion from Kupffer cells Characterization of species C human adenovirus serotype 6 (Ad6)The challenge for gene therapy: innate immune response to adenoviruses Tumor vascular targeted delivery of polymer-conjugated adenovirus vector for cancer gene therapy Increasing the efficacy of oncolytic adenovirus vectors Polyinosinic acid decreases sequestration and improves systemic therapy of measles virus.Protection of adenovirus from neutralizing antibody by cationic PEG derivative ionically linked to adenovirus Identification of adenovirus serotype 5 hexon regions that interact with scavenger receptors.Polymeric oncolytic adenovirus for cancer gene therapy.A vesicular stomatitis virus glycoprotein epitope-incorporated oncolytic adenovirus overcomes CAR-dependency and shows markedly enhanced cancer cell killing and suppression of tumor growth.Evaluation of polymer shielding for adenovirus serotype 6 (Ad6) for systemic virotherapy against human prostate cancers.Trial watch: Oncolytic viruses for cancer therapy Oncolytic (replication-competent) adenoviruses as anticancer agents.Advances and future challenges in adenoviral vector pharmacology and targeting.Manipulation of adenovirus interactions with host factors for gene therapy applications.Oncolytic virotherapy The evolution of adenoviral vectors through genetic and chemical surface modifications.Sorting Out Pandora's Box: Discerning the Dynamic Roles of Liver Microenvironment in Oncolytic Virus Therapy for Hepatocellular Carcinoma.Changing faces in virology: the dutch shift from oncogenic to oncolytic viruses.Adenoviruses as gene/vaccine delivery vectors: promises and pitfalls.Advances in systemic delivery of anti-cancer agents for the treatment of metastatic cancer.Oncolytic virotherapy for urological cancers.Oncolytic virotherapy: the questions and the promise.Oncolytic virus therapy for cancer.Viral dose, radioiodide uptake, and delayed efflux in adenovirus-mediated NIS radiovirotherapy correlates with treatment efficacy.PEGylation of vesicular stomatitis virus extends virus persistence in blood circulation of passively immunized mice.Systemic virotherapy for multiple myeloma.Barriers to systemic application of virus-based vectors in gene therapy: lessons from adenovirus type 5.Phase 1 study of intravenous administration of the chimeric adenovirus enadenotucirev in patients undergoing primary tumor resection.Imaging luciferase-expressing viruses.Comparison of Liver Detargeting Strategies for Systemic Therapy with Oncolytic Adenovirus Serotype 5.

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P2860

Chemical modification with high molecular weight polyethylene glycol reduces transduction of hepatocytes and increases efficacy of intravenously delivered oncolytic adenovirus

http://www.wikidata.org/entity/Q33690982

description

2009 nî lūn-bûn

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2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Chemical modification with hig ...... delivered oncolytic adenovirus

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Chemical modification with hig ...... delivered oncolytic adenovirus

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Human Gene Therapy

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Chemical modification with hig ...... delivered oncolytic adenovirus

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P2093

Elena V Shashkova

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Konstantin Doronin

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Michael A Barry

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Sean E Hofherr

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Shannon M May

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P2860

Advances in PEGylation of important biotech molecules: delivery aspects

PEGylated helper-dependent adenoviral vectors: highly efficient vectors with an enhanced safety profile.

Redundant and synergistic mechanisms control the sequestration of blood-born adenovirus in the liver.

Tumor-specific, replication-competent adenovirus vectors overexpressing the adenovirus death protein

Tissue-specific, tumor-selective, replication-competent adenovirus vector for cancer gene therapy.

"Stealth" adenoviruses blunt cell-mediated and humoral immune responses against the virus and allow for significant gene expression upon readministration in the lung

Dual cancer-specific targeting strategy cures primary and distant breast carcinomas in nude mice.

Effects of shielding adenoviral vectors with polyethylene glycol on vector-specific and vaccine-mediated immune responses.

Clinical research results with dl1520 (Onyx-015), a replication-selective adenovirus for the treatment of cancer: what have we learned?

Modification of adenovirus gene transfer vectors with synthetic polymers: a scientific review and technical guide.

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975-988

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10.1089/HUM.2009.028

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9

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20

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26241178

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19469693

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oncolytic virus

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2829283

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