The WTX/AMER1 gene family: evolution, signature and function
about
Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutationsAmer2 protein is a novel negative regulator of Wnt/β-catenin signaling involved in neuroectodermal patterningAdenomatous polyposis coli (APC) membrane recruitment 3, a member of the APC membrane recruitment family of APC-binding proteins, is a positive regulator of Wnt-β-catenin signallingFAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility.The lineage-specific gene ponzr1 is essential for zebrafish pronephric and pharyngeal arch development.Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners.Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration.β-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein.A knock-in mouse line conditionally expressing the tumor suppressor WTX/AMER1.
P2860
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P2860
The WTX/AMER1 gene family: evolution, signature and function
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The WTX/AMER1 gene family: evolution, signature and function
@ast
The WTX/AMER1 gene family: evolution, signature and function
@en
type
label
The WTX/AMER1 gene family: evolution, signature and function
@ast
The WTX/AMER1 gene family: evolution, signature and function
@en
prefLabel
The WTX/AMER1 gene family: evolution, signature and function
@ast
The WTX/AMER1 gene family: evolution, signature and function
@en
P2860
P356
P1476
The WTX/AMER1 gene family: evolution, signature and function
@en
P2093
Agnès Boutet
P2860
P2888
P356
10.1186/1471-2148-10-280
P577
2010-09-15T00:00:00Z
P5875
P6179
1030320005