Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia. - Wikidata - awgldk - TriplyDB

Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia.

Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia.

http://www.wikidata.org/entity/Q33694514

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Drugging the unfolded protein response in acute leukemias Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases The unfolded protein response in immunity and inflammation The burden of trisomy 21 disrupts the proteostasis network in Down syndrome.The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress A Covalent Cysteine-Targeting Kinase Inhibitor of Ire1 Permits Allosteric Control of Endoribonuclease Activity.X-Box-Binding Protein 1 and Innate Immune Responses of Human Cystic Fibrosis Alveolar Macrophages.Deregulated expression of the HSP40 family members Auxilin-1 and -2 is indicative of proteostasis imbalance and predicts patient outcome in Ph(+) leukemia.Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress.Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia.Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 1. An overview.Novel Gene and Network Associations Found for Acute Lymphoblastic Leukemia Using Case-Control and Family-Based Studies in Multiethnic Populations.Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells.WNT16-expressing Acute Lymphoblastic Leukemia Cells are Sensitive to Autophagy Inhibitors after ER Stress Induction.Endoplasmic reticulum proteostasis: a key checkpoint in cancer.Targeting the unfolded protein response in cancer.The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics The Unfolded Protein Response in the Immune Cell Development: Putting the Caretaker in the Driving Seat.Valosin-Containing Protein/p97 as a Novel Therapeutic Target in Acute Lymphoblastic Leukemia.Targeting protein quality control pathways in breast cancer.In vitro efficacy of a first-generation valosin-containing protein inhibitor (CB-5083) against canine lymphoma.TUSC3: functional duality of a cancer gene.Eviction from the sanctuary: Development of targeted therapy against cell adhesion molecules in acute lymphoblastic leukemia.Inhibition of the NEDD8 conjugation pathway induces calcium-dependent compensatory activation of the pro-survival MEK/ERK pathway in acute lymphoblastic leukemia.Unfolded Protein Response of the Endoplasmic Reticulum in Tumor Progression and Immunogenicity.Driving Cancer Tumorigenesis and Metastasis Through UPR Signaling.3' enhancers hs3b/hs4 are dispensable for deregulation in mouse plasmacytomas with T(12;15) translocations Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases

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P2860

Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia.

http://www.wikidata.org/entity/Q33694514

description

2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Mechanistic rationale for targ ...... acute lymphoblastic leukemia.

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Mechanistic rationale for targ ...... acute lymphoblastic leukemia.

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type

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Mechanistic rationale for targ ...... acute lymphoblastic leukemia.

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Mechanistic rationale for targ ...... acute lymphoblastic leukemia.

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Mechanistic rationale for targ ...... acute lymphoblastic leukemia.

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Mechanistic rationale for targ ...... acute lymphoblastic leukemia.

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PNAS.1400958111

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Proceedings of the National Academy of Sciences of the United States of America

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Mechanistic rationale for targ ...... acute lymphoblastic leukemia.

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Aaron C Logan

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Ari M Melnick

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Behzad Kharabi Masouleh

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Christian Hurtz

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Chuanxin Huang

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Haibo Sun

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Huimin Geng

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Lai N Chan

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Markus Müschen

http://www.w3.org/2001/XMLSchema#string

Mi Sook Chang

http://www.w3.org/2001/XMLSchema#string

P2860

Plasma cell differentiation requires the transcription factor XBP-1

Roles of CHOP/GADD153 in endoplasmic reticulum stress

Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK.

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program

Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells

Immunoglobulin heavy chain binding protein

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111

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Markus Müschen

Elisabeth Paietta

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2014-05-12T00:00:00Z

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