EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium.
about
CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinantEndocrinology and hormone therapy in breast cancer: selective oestrogen receptor modulators and downregulators for breast cancer - have they lost their way?Therapeutic options for management of endometrial hyperplasiaKinetic analysis of estrogen receptor/ligand interactions.Synthesis and structure-activity relationships of analogs of EM-652 (acolbifene), a pure selective estrogen receptor modulator. Study of nitrogen substitution.Chemoprevention for high-risk women: tamoxifen and beyond.Designing and optimization of novel human LMTK3 inhibitors against breast cancer - a computational approach.Clinical Trial of Acolbifene in Premenopausal Women at High Risk for Breast Cancer.Molecular classification of selective oestrogen receptor modulators on the basis of gene expression profiles of breast cancer cells expressing oestrogen receptor alpha.Antitumor agents. 266. Design, synthesis, and biological evaluation of novel 2-(furan-2-yl)naphthalen-1-ol derivatives as potent and selective antibreast cancer agents.The selective estrogen receptor modulator SCH 57068 prevents bone loss, reduces serum cholesterol and blocks estrogen-induced uterine hypertrophy in ovariectomized rats.Characterization of ligand type of estrogen receptor by MD simulation and mm-PBSA free energy analysis.Biological evaluation and SAR analysis of O-methylated analogs of quercetin as inhibitors of cancer cell proliferation.Benzothiepin-derived molecular scaffolds for estrogen receptor modulators: synthesis and antagonistic effects in breast cancer cells.Effect of toremifene and ospemifene, compared to acolbifene, on estrogen-sensitive parameters in rat and human uterine tissues.Comparison of the effects of EM-652 (SCH57068), tamoxifen, toremifene, droloxifene, idoxifene, GW-5638 and raloxifene on the growth of human ZR-75-1 breast tumors in nude mice.Estradiol reduces F2alpha-isoprostane production in cultured human endothelial cells.The estrogen antagonist EM-652 and dehydroepiandrosterone prevent diet- and ovariectomy-induced obesity.Mouse bioassay to assess oestrogenic and anti-oestrogenic compounds: hydroxytamoxifen, diethylstilbestrol and genistein.Hypolipidemic action of the SERM acolbifene is associated with decreased liver MTP and increased SR-BI and LDL receptors.Estrogen receptor alpha-mediated adiposity-lowering and hypocholesterolemic actions of the selective estrogen receptor modulator acolbifene.Mouse bioassay for in vivo screening of oestrogen and progesterone antagonists.Development of the β-lactam type molecular scaffold for selective estrogen receptor α modulator action: synthesis and cytotoxic effects in MCF-7 breast cancer cells.Identification of curcumin derivatives as human LMTK3 inhibitors for breast cancer: a docking, dynamics, and MM/PBSA approach.
P2860
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P2860
EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium.
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
EM-652 (SCH 57068), a third ge ...... mammary gland and endometrium.
@ast
EM-652 (SCH 57068), a third ge ...... mammary gland and endometrium.
@en
type
label
EM-652 (SCH 57068), a third ge ...... mammary gland and endometrium.
@ast
EM-652 (SCH 57068), a third ge ...... mammary gland and endometrium.
@en
prefLabel
EM-652 (SCH 57068), a third ge ...... mammary gland and endometrium.
@ast
EM-652 (SCH 57068), a third ge ...... mammary gland and endometrium.
@en
P2093
P1476
EM-652 (SCH 57068), a third ge ...... mammary gland and endometrium.
@en
P2093
Bélanger A
Charbonneau R
Charpenet G
Fournier M
Gauthier S
P356
10.1016/S0960-0760(99)00065-5
P577
1999-04-01T00:00:00Z