17alpha-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response.
about
Androgen biosynthesis in castration-resistant prostate cancerDistinct and redundant functions of cyclin E1 and cyclin E2 in development and cancerVN/14-1 induces ER stress and autophagy in HP-LTLC human breast cancer cells and has excellent oral pharmacokinetic profile in female Sprague Dawley ratsTargeting drug-metabolizing enzymes for effective chemoprevention and chemotherapy.Advances in small molecule inhibitors of androgen receptor for the treatment of advanced prostate cancer.CYP17 inhibitors--abiraterone, C17,20-lyase inhibitors and multi-targeting agents.CYP17A1 inhibitors in castration-resistant prostate cancerNew hormonal therapies for castration-resistant prostate cancer.Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer xenografts in vivo.Prostate cancer and the unfolded protein response.Autophagy inhibition synergistically enhances anticancer efficacy of RAMBA, VN/12-1 in SKBR-3 cells, and tumor xenograftsAssociation of serum calcium with serum sex steroid hormones in men in NHANES III.New agents and strategies for the hormonal treatment of castration-resistant prostate cancer.Targeting alternative sites on the androgen receptor to treat castration-resistant prostate cancer.Evolution of androgen receptor targeted therapy for advanced prostate cancer.Galeterone and VNPT55 disrupt Mnk-eIF4E to inhibit prostate cancer cell migration and invasion.Direct regulation of androgen receptor activity by potent CYP17 inhibitors in prostate cancer cells.Synthesis of novel 4-(1H-benzimidazol-2-yl)benzene-1,3-diols and their cytotoxic activity against human cancer cell lines.Biological and clinical effects of abiraterone on anti-resorptive and anabolic activity in bone microenvironment.Galeterone and its analogs inhibit Mnk-eIF4E axis, synergize with gemcitabine, impede pancreatic cancer cell migration, invasion and proliferation and inhibit tumor growth in miceGaleterone prevents androgen receptor binding to chromatin and enhances degradation of mutant androgen receptor.Identification of Novel Steroidal Androgen Receptor Degrading Agents Inspired by Galeterone 3β-Imidazole CarbamateNovel galeterone analogs act independently of AR and AR-V7 for the activation of the unfolded protein response and induction of apoptosis in the CWR22Rv1 prostate cancer cell model.The unidirectional hypoxia-activated prodrug OCT1002 inhibits growth and vascular development in castrate-resistant prostate tumors.
P2860
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P2860
17alpha-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response.
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
17alpha-Hydroxylase/17,20 lyas ...... mic reticulum stress response.
@ast
17alpha-Hydroxylase/17,20 lyas ...... mic reticulum stress response.
@en
type
label
17alpha-Hydroxylase/17,20 lyas ...... mic reticulum stress response.
@ast
17alpha-Hydroxylase/17,20 lyas ...... mic reticulum stress response.
@en
prefLabel
17alpha-Hydroxylase/17,20 lyas ...... mic reticulum stress response.
@ast
17alpha-Hydroxylase/17,20 lyas ...... mic reticulum stress response.
@en
P2093
P2860
P1476
17alpha-Hydroxylase/17,20 lyas ...... smic reticulum stress response
@en
P2093
Angela M Brodie
Angelika M Burger
Tony D Gover
P2860
P304
P356
10.1158/1535-7163.MCT-08-0336
P577
2008-09-01T00:00:00Z