Phosphorylation of VACM-1/Cul5 by protein kinase A regulates its neddylation and antiproliferative effect.
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The role of cullin 5-containing ubiquitin ligasesVACM-1/cul5 expression in vascular tissue in vivo is induced by water deprivation and its expression in vitro regulates aquaporin-1 concentrations.Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65.Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182.Mutational analysis of VACM-1/cul5 exons in cancer cell lines.Resveratrol enhances anti-proliferative effect of VACM-1/cul5 in T47D cancer cells.SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase functionNuclear localization signal sequence is required for VACM-1/CUL5-dependent regulation of cellular growth.CUL5 is required for thalidomide-dependent inhibition of cellular proliferation.
P2860
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P2860
Phosphorylation of VACM-1/Cul5 by protein kinase A regulates its neddylation and antiproliferative effect.
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Phosphorylation of VACM-1/Cul5 ...... and antiproliferative effect.
@ast
Phosphorylation of VACM-1/Cul5 ...... and antiproliferative effect.
@en
type
label
Phosphorylation of VACM-1/Cul5 ...... and antiproliferative effect.
@ast
Phosphorylation of VACM-1/Cul5 ...... and antiproliferative effect.
@en
prefLabel
Phosphorylation of VACM-1/Cul5 ...... and antiproliferative effect.
@ast
Phosphorylation of VACM-1/Cul5 ...... and antiproliferative effect.
@en
P2093
P2860
P356
P1476
Phosphorylation of VACM-1/Cul5 ...... and antiproliferative effect.
@en
P2093
Alyssa E Johnson
Elizabeth Oosterhouse
Gabriel A Marquez
Isabelle P Le
Maria Burnatowska-Hledin
Michael P Hledin
Shirley E Bradley
P2860
P304
P356
10.1074/JBC.M109.085225
P407
P577
2009-11-16T00:00:00Z