Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress.

Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress.

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http://www.wikidata.org/entity/Q33718487
Improving anticancer drug development begins with cell culture: misinformation perpetrated by the misuse of cytotoxicity assaysCryptosporidium Lactate Dehydrogenase Is Associated with the Parasitophorous Vacuole Membrane and Is a Potential Target for Developing TherapeuticsAristolochic acid, a plant extract used in the treatment of pain and linked to Balkan endemic nephropathy, is a regulator of K2P channels.Rapid induction of apoptosis in chronic lymphocytic leukemia cells by the microtubule disrupting agent BNC105.Dietary gossypol suppressed postprandial TOR signaling and elevated ER stress pathways in turbot (Scophthalmus maximus L.).AT-101 inhibits hedgehog pathway activity and cancer growth.BCL2 Inhibitors as Anticancer Drugs: A Plethora of Misleading BH3 Mimetics.Assessment of HTLV-1 proviral load, LAT, BIM, c-FOS and RAD51 gene expression in adult T cell leukemia/lymphoma.Gossypol sensitizes the antitumor activity of 5-FU through down-regulation of thymidylate synthase in human colon carcinoma cells.Exploiting the pro-apoptotic function of NOXA as a therapeutic modality in cancer.Pathways and mechanisms of venetoclax resistance.Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity
P2860

Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress.

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http://www.wikidata.org/entity/Q33718487
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Gossypol increases expression ...... endoplasmic reticulum stress.
@ast
Gossypol increases expression ...... endoplasmic reticulum stress.
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Gossypol increases expression ...... endoplasmic reticulum stress.
@ast
Gossypol increases expression ...... endoplasmic reticulum stress.
@en
prefLabel
Gossypol increases expression ...... endoplasmic reticulum stress.
@ast
Gossypol increases expression ...... endoplasmic reticulum stress.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932
P356
P1433
P1476
Gossypol increases expression ...... endoplasmic reticulum stress.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932