Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts.
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Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in RatsThrombin induced connective tissue growth factor expression in rat vascular smooth muscle cells via the PAR-1/JNK/AP-1 pathway.Uncoupling of the profibrotic and hemostatic effects of thrombin in lung fibrosis.Thrombin increases lung fibroblast survival while promoting alveolar epithelial cell apoptosis via the endoplasmic reticulum stress marker, CCAAT enhancer-binding homologous proteinFibrosis: recent advances in myofibroblast biology and new therapeutic perspectives.The mechanical environment modulates intracellular calcium oscillation activities of myofibroblasts.Coagulation and autoimmunity in scleroderma interstitial lung disease.An immunohistochemical analysis of tissue thrombin expression in the human atriaAntiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease.Activation of protease-activated receptors (PARs)-1 and -2 promotes alpha-smooth muscle actin expression and release of cytokines from human lung fibroblastsPathogenesis of Systemic Sclerosis.Dabigatran abrogates brain endothelial cell permeability in response to thrombin.Concerns regarding the use of dabigatran for stroke prevention in atrial fibrillation.Treatment of Rapidly Progressive Systemic Sclerosis: Current and Futures PerspectivesThe multivalent activity of the tissue factor-thrombin pathway in thrombotic and non-thrombotic disorders as a target for therapeutic intervention.Novel investigational agents for the treatment of scleroderma.Recent advances in understanding the pathogenesis of scleroderma-interstitial lung disease.Review: Frontiers of Antifibrotic Therapy in Systemic Sclerosis.Stromal and immune cells in gut fibrosis: the myofibroblast and the scarface.High endogenous activated protein C levels attenuates bleomycin-induced pulmonary fibrosis.Thrombin-induced CCN2 expression as a target for anti-fibrotic therapy in scleroderma.The discovery of dabigatran etexilate.Reply: rationale for anticoagulant therapy of pulmonary fibrosisTissue factor-thrombin signaling enhances the fibrotic activity of myofibroblasts in systemic sclerosis through up-regulation of endothelin receptor A.Should vitamin K be supplemented instead of antagonised in patients with idiopathic pulmonary fibrosis?Roles of high-mobility group box 1 and thrombin in murine pulmonary fibrosis and the therapeutic potential of thrombomodulin.Direct thrombin inhibition with dabigatran attenuates pressure overload-induced cardiac fibrosis and dysfunction in mice.Serum analysis of coagulation factors in IPF and NSIP.Idiopathic Pulmonary Fibrosis: Molecular Endotypes of Fibrosis Stratifying Existing and Emerging Therapies.First Evidence: TRAP-Induced Platelet Aggregation Is Reduced in Patients Receiving Xabans.Thrombin Receptor Agonist Peptide-Induced Platelet Aggregation Is Reduced in Patients Receiving Dabigatran.Use of biologics and other novel therapies for the treatment of systemic sclerosis.Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation.Curcumin inhibits thrombin-stimulated connective tissue growth factor (CTGF/CCN2) production through c-Jun NH2-terminal kinase suppression in human gingival fibroblasts.Hematopoietic protease nexin-1 protects against lung injury by preventing thrombin signaling in mice87-year-old woman with improved pulmonary function following accidental long-term inhalation therapy with dabigatran
P2860
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P2860
Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts.
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Dabigatran, a direct thrombin ...... c effects on lung fibroblasts.
@ast
Dabigatran, a direct thrombin ...... c effects on lung fibroblasts.
@en
type
label
Dabigatran, a direct thrombin ...... c effects on lung fibroblasts.
@ast
Dabigatran, a direct thrombin ...... c effects on lung fibroblasts.
@en
prefLabel
Dabigatran, a direct thrombin ...... c effects on lung fibroblasts.
@ast
Dabigatran, a direct thrombin ...... c effects on lung fibroblasts.
@en
P2860
P356
P1476
Dabigatran, a direct thrombin ...... ic effects on lung fibroblasts
@en
P2093
Galina S Bogatkevich
Richard M Silver
P2860
P304
P356
10.1002/ART.24935
P577
2009-11-01T00:00:00Z