Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.
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P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferationKRAS Mutant Pancreatic Cancer: No Lone Path to an Effective TreatmentPI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasmsAMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation.Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)The critical role of Akt in cardiovascular functionEmerging methodologies to investigate lipid-protein interactionsNovel cancer chemotherapy hits by molecular topology: dual Akt and Beta-catenin inhibitorsDevelopment of sulfonamide AKT PH domain inhibitors.PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes association with 14-3-3γ and is required for metaphase-anaphase transition.Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain.Small-molecule inhibitors of the PI3K signaling networkInhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape.Identification of a novel class of anti-inflammatory compounds with anti-tumor activity in colorectal and lung cancers.From laptop to benchtop to bedside: structure-based drug design on protein targets.Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer.Inhibition of HIV-1 Tat-mediated transcription by a coumarin derivative, BPRHIV001, through the Akt pathway.PLEKHA5 as a Biomarker and Potential Mediator of Melanoma Brain Metastasis.Targeting the PI3K/Akt/mTOR pathway--beyond rapalogsThe Akt signaling pathway: an emerging therapeutic target in malignant melanoma.Exploitation of the ability of γ-tocopherol to facilitate membrane co-localization of Akt and PHLPP1 to develop PHLPP1-targeted Akt inhibitorsp110δ PI3 kinase pathway: emerging roles in cancer.Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin.Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.Estrogen receptor-positive breast cancer molecular signatures and therapeutic potentials (Review).Recent development of anticancer therapeutics targeting Akt.Genomic Determinants of PI3K Pathway Inhibitor Response in Cancer.AKT as a therapeutic target in multiple myeloma.Target and Agent Prioritization for the Children's Oncology Group-National Cancer Institute Pediatric MATCH Trial.NSC126188 induces apoptosis of prostate cancer PC-3 cells through inhibition of Akt membrane translocation, FoxO3a activation, and RhoB transcription.Toxicological effects of NCKU-21, a phenanthrene derivative, on cell growth and migration of A549 and CL1-5 human lung adenocarcinoma cells.Improved Treatment of Pancreatic Cancer With Drug Delivery Nanoparticles Loaded With a Novel AKT/PDK1 Inhibitor.DawnRank: discovering personalized driver genes in cancer.Insights into the inhibitory mechanism of triazole-based small molecules on phosphatidylinositol-4,5-bisphosphate binding pleckstrin homology domain.Protein Kinase Targets in Breast Cancer.A microfluidics platform for combinatorial drug screening on cancer biopsies.Chlorogenic Acid Targeting of the AKT PH Domain Activates AKT/GSK3β/FOXO1 Signaling and Improves Glucose Metabolism
P2860
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P2860
Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Molecular pharmacology and ant ...... rin homology domain inhibitor.
@ast
Molecular pharmacology and ant ...... rin homology domain inhibitor.
@en
type
label
Molecular pharmacology and ant ...... rin homology domain inhibitor.
@ast
Molecular pharmacology and ant ...... rin homology domain inhibitor.
@en
prefLabel
Molecular pharmacology and ant ...... rin homology domain inhibitor.
@ast
Molecular pharmacology and ant ...... rin homology domain inhibitor.
@en
P2093
P2860
P1476
Molecular pharmacology and ant ...... rin homology domain inhibitor.
@en
P2093
Ali M Ahad
D Lynn Kirkpatrick
Emmanuelle J Meuillet
Eugene A Mash
John Kingston
Jörg J Jacoby
Lei Du-Cuny
Li Li Zhou
Nathan Ihle
Robert Lemos
P2860
P304
P356
10.1158/1535-7163.MCT-09-0985
P577
2010-03-02T00:00:00Z