Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition
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Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart diseaseTRP-ing up heart and vessels: canonical transient receptor potential channels and cardiovascular diseaseSignaling effectors underlying pathologic growth and remodeling of the heartTherapeutic potential of PDE modulation in treating heart diseasePhosphodiesterases and cardiac cGMP: evolving roles and controversiesDominant negative Ras attenuates pathological ventricular remodeling in pressure overload cardiac hypertrophyCitrullination of myofilament proteins in heart failure.cAMP and Ca²⁺ signaling in secretory epithelia: crosstalk and synergism.Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity.Cardiac cyclic nucleotide phosphodiesterases: function, regulation, and therapeutic prospects.Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis.cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.Cyclic guanosine monophosphate signaling and phosphodiesterase-5 inhibitors in cardioprotection.Protein kinase G I and heart failure: Shifting focus from vascular unloading to direct myocardial antiremodeling effects.Acetylcholine promotes Ca2+ and NO-oscillations in adipocytes implicating Ca2+→NO→cGMP→cADP-ribose→Ca2+ positive feedback loop--modulatory effects of norepinephrine and atrial natriuretic peptideThree 4-letter words of hypertension-related cardiac hypertrophy: TRPC, mTOR, and HDAC.Reducing endoglin activity limits calcineurin and TRPC-6 expression and improves survival in a mouse model of right ventricular pressure overload.Role of TRP channels in the cardiovascular system.A cardiac pathway of cyclic GMP-independent signaling of guanylyl cyclase A, the receptor for atrial natriuretic peptidePrevention of PKG1α oxidation augments cardioprotection in the stressed heart.Cardiac role of cyclic-GMP hydrolyzing phosphodiesterase type 5: from experimental models to clinical trials.Regression of pathological cardiac hypertrophy: signaling pathways and therapeutic targets.Effects on polo-like kinase 1 polo-box domain binding affinities of peptides incurred by structural variation at the phosphoamino acid position.Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart.NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growthGain-of-function mutations in transient receptor potential C6 (TRPC6) activate extracellular signal-regulated kinases 1/2 (ERK1/2)Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap.Old dog, new tricks: novel cardiac targets and stress regulation by protein kinase G.Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-γ signaling axisTadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts.Translocation of PKG1α acts on TRPV4-C1 heteromeric channels to inhibit endothelial Ca(2+) entrySildenafil inhibits hypoxia-induced transient receptor potential canonical protein expression in pulmonary arterial smooth muscle via cGMP-PKG-PPARγ axisIntermittent hypoxia-induced increases in reactive oxygen species activate NFATc3 increasing endothelin-1 vasoconstrictor reactivity.Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy.Hyperactive adverse mechanical stress responses in dystrophic heart are coupled to transient receptor potential canonical 6 and blocked by cGMP-protein kinase G modulation.Pathophysiology and therapy of cardiac dysfunction in Duchenne muscular dystrophy.Modulatory Role of Nitric Oxide/cGMP System in Endothelin-1-Induced Signaling Responses in Vascular Smooth Muscle CellsRegulation of cardiovascular TRP channel functions along the NO-cGMP-PKG axis.Phosphodiesterases and cyclic GMP regulation in heart muscle.Protein kinase G signaling in cardiac pathophysiology: Impact of proteomics on clinical trials.
P2860
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P2860
Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Cyclic GMP/PKG-dependent inhib ...... modulation by PDE5 inhibition
@ast
Cyclic GMP/PKG-dependent inhib ...... modulation by PDE5 inhibition
@en
type
label
Cyclic GMP/PKG-dependent inhib ...... modulation by PDE5 inhibition
@ast
Cyclic GMP/PKG-dependent inhib ...... modulation by PDE5 inhibition
@en
prefLabel
Cyclic GMP/PKG-dependent inhib ...... modulation by PDE5 inhibition
@ast
Cyclic GMP/PKG-dependent inhib ...... modulation by PDE5 inhibition
@en
P2093
P2860
P1476
Cyclic GMP/PKG-dependent inhib ...... modulation by PDE5 inhibition
@en
P2093
David A Kass
Eiki Takimoto
Geoffrey G Hesketh
Gordon F Tomaselli
Janelle Rowell
Manling Zhang
Norimichi Koitabashi
Takeshi Aiba
P2860
P304
P356
10.1016/J.YJMCC.2009.11.015
P577
2009-12-01T00:00:00Z