Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene.
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The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificityDiscoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagenThe metzincins--topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidasesElucidation of the potential roles of matrix metalloproteinases in skeletal biologyCollagenolytic Matrix Metalloproteinase Activities toward Peptomeric Triple-Helical SubstratesMechanical strain stabilizes reconstituted collagen fibrils against enzymatic degradation by mammalian collagenase matrix metalloproteinase 8 (MMP-8)Structural interaction of natural and synthetic inhibitors with the venom metalloproteinase, atrolysin C (form d)Different collagenase gene products have different roles in degradation of type I collagenA targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodelingMatrix metalloproteinases in repair.Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice.Diffusion of MMPs on the surface of collagen fibrils: the mobile cell surface-collagen substratum interface.Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen.Local conformation and dynamics of isoleucine in the collagenase cleavage site provide a recognition signal for matrix metalloproteinases.Matrix metalloproteinases and collagen catabolism.Collagenase-resistant collagen promotes mouse aging and vascular cell senescenceOsteocyte and osteoblast apoptosis and excessive bone deposition accompany failure of collagenase cleavage of collagenDouble replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells.Matrix metalloproteinase 14 is required for fibrous tissue expansionFibronectin binding site in type I collagen regulates fibronectin fibril formation.Type V collagen: molecular structure and fibrillar organization of the chicken alpha 1(V) NH2-terminal domain, a putative regulator of corneal fibrillogenesis.The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix.Regulation of collagen I gene expression by rasPeri-adipocyte ECM remodeling in obesity and adipose tissue fibrosis.Shedding of discoidin domain receptor 1 by membrane-type matrix metalloproteinases.The Xenopus laevis isoform of G protein-coupled receptor 3 (GPR3) is a constitutively active cell surface receptor that participates in maintaining meiotic arrest in X. laevis oocytes.Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences.Limiting collagen turnover via collagenase-resistance attenuates right ventricular dysfunction and fibrosis in pulmonary arterial hypertension.3D/4D functional imaging of tumor-associated proteolysis: impact of microenvironment.Altered endochondral bone development in matrix metalloproteinase 13-deficient mice.Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis.The role of collagen charge clusters in the modulation of matrix metalloproteinase activity.Synthesis and biological applications of collagen-model triple-helical peptides.Extracellular matrix roles during cardiac repair.Dynamic interplay between the collagen scaffold and tumor evolution.Procollagen with skipping of alpha 1(I) exon 41 has lower binding affinity for alpha 1(I) C-telopeptide, impaired in vitro fibrillogenesis, and altered fibril morphology.Matrix metalloproteinase collagenolysis in health and disease.Type I collagen cleavage is essential for effective fibrotic repair after myocardial infarction.The desmoplastic reaction surrounding hepatic colorectal adenocarcinoma metastases aids tumor growth and survival via alphav integrin ligation.Reaction diffusion model of the enzymatic erosion of insoluble fibrillar matrices.
P2860
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P2860
Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene.
description
1990 nî lūn-bûn
@nan
1990 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Generation of collagenase-resi ...... pro alpha 1(I) collagen gene.
@ast
Generation of collagenase-resi ...... pro alpha 1(I) collagen gene.
@en
type
label
Generation of collagenase-resi ...... pro alpha 1(I) collagen gene.
@ast
Generation of collagenase-resi ...... pro alpha 1(I) collagen gene.
@en
prefLabel
Generation of collagenase-resi ...... pro alpha 1(I) collagen gene.
@ast
Generation of collagenase-resi ...... pro alpha 1(I) collagen gene.
@en
P2093
P2860
P356
P1476
Generation of collagenase-resi ...... pro alpha 1(I) collagen gene.
@en
P2093
P2860
P304
P356
10.1073/PNAS.87.15.5888
P577
1990-08-01T00:00:00Z