PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha
about
Crystal structure of eukaryotic translation initiation factor 2BDouble-stranded RNA-activated protein kinase PKR of fishes and amphibians: varying the number of double-stranded RNA binding domains and lineage-specific duplications.GCN2 phosphorylates HIV-1 integrase and decreases HIV-1 replication by limiting viral integration.Protein synthesis attenuation by phosphorylation of eIF2α is required for the differentiation of Trypanosoma cruzi into infective forms.Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation.The beta/Gcd7 subunit of eukaryotic translation initiation factor 2B (eIF2B), a guanine nucleotide exchange factor, is crucial for binding eIF2 in vivoRequirement for kinase-induced conformational change in eukaryotic initiation factor 2alpha (eIF2alpha) restricts phosphorylation of Ser51.An eIF2α-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2α.The amino terminus of the vaccinia virus E3 protein is necessary to inhibit the interferon responseActivation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK.Novel membrane-bound eIF2alpha kinase in the flagellar pocket of Trypanosoma bruceidsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection.Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae.Variola virus E3L Zα domain, but not its Z-DNA binding activity, is required for PKR inhibitionActivation of protein kinase PKR requires dimerization-induced cis-phosphorylation within the activation loop.Phosphorylation of eIF2α on Threonine 169 is not required for Trypanosoma brucei cell cycle arrest during differentiation.Evolution of the archaeal and mammalian information processing systems: towards an archaeal model for human disease.Essential amino acids regulate both initiation and elongation of mRNA translation independent of insulin in MAC-T cells and bovine mammary tissue slices.eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control.Molecular dynamics reveal a novel kinase-substrate interface that regulates protein translation.Residues required for phosphorylation of translation initiation factor eIF2α under diverse stress conditions are divergent between yeast and human.Mae inhibits Pointed-P2 transcriptional activity by blocking its MAPK docking site.Activation of the integrated stress response during T helper cell differentiation.SMN deficiency reduces cellular ability to form stress granules, sensitizing cells to stress.
P2860
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P2860
PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha
description
2005 nî lūn-bûn
@nan
2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
PKR and GCN2 kinases and guani ...... rlapping surfaces on eIF2alpha
@ast
PKR and GCN2 kinases and guani ...... rlapping surfaces on eIF2alpha
@en
type
label
PKR and GCN2 kinases and guani ...... rlapping surfaces on eIF2alpha
@ast
PKR and GCN2 kinases and guani ...... rlapping surfaces on eIF2alpha
@en
prefLabel
PKR and GCN2 kinases and guani ...... rlapping surfaces on eIF2alpha
@ast
PKR and GCN2 kinases and guani ...... rlapping surfaces on eIF2alpha
@en
P2093
P2860
P1476
PKR and GCN2 kinases and guani ...... rlapping surfaces on eIF2alpha
@en
P2093
Arvin C Dar
Bruce Trieselmann
Emily G Locke
Frank Sicheri
Jingfang Lu
Jinsheng Dong
Madhusudan Dey
Thanuja Krishnamoorthy
P2860
P304
P356
10.1128/MCB.25.8.3063-3075.2005
P407
P50
P577
2005-04-01T00:00:00Z