Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. - Wikidata - awgldk - TriplyDB

Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.

Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.

http://www.wikidata.org/entity/Q33735612

about

Chronic over-nutrition and dysregulation of GSK3 in diseases Insulin Resistance and Endothelial Dysfunction Constitute a Common Therapeutic Target in Cardiometabolic Disorders Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)The critical role of Akt in cardiovascular function Emerging methodologies to investigate lipid-protein interactions Efficacy of a non-hypercalcemic vitamin-D2 derived anti-cancer agent (MT19c) and inhibition of fatty acid synthesis in an ovarian cancer xenograft model Development of a human breast-cancer derived cell line stably expressing a bioluminescence resonance energy transfer (BRET)-based phosphatidyl inositol-3 phosphate (PIP3) biosensor Could the Ebola virus matrix protein VP40 be a drug target?The multifunctional Ebola virus VP40 matrix protein is a promising therapeutic target.Development of sulfonamide AKT PH domain inhibitors.Signal integration by lipid-mediated spatial cross talk between Ras nanoclusters Polyisoprenylated cysteinyl amide inhibitors disrupt actin cytoskeleton organization, induce cell rounding and block migration of non-small cell lung cancer.Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain.Small-molecule inhibitors of the PI3K signaling network Macrophage-activating lipopeptide-2 requires Mal and PI3K for efficient induction of heme oxygenase-1.Disulphide bridges of phospholipase C of Chlamydomonas reinhardtii modulates lipid interaction and dimer stability Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis.SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer Targeting the PI3K/Akt/mTOR pathway in hepatocellular carcinoma.Optimization of the anti-cancer activity of phosphatidylinositol-3 kinase pathway inhibitor PITENIN-1: switching a thiourea with 1,2,3-triazole A HPLC method for the quantitative determination of N-(2-hydroxy-5-nitrophenylcarbamothioyl)-3,5-dimethylbenzamide in biological samples.Immunomodulatory activity of a novel, synthetic beta-glucan (β-glu6) in murine macrophages and human peripheral blood mononuclear cells.Guidelines for visualizing and annotating rule-based models Phosphoinositide binding differentially regulates NHE1 Na+/H+ exchanger-dependent proximal tubule cell survival Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis.New Frontiers in Druggability Inhibition of cell migration by PITENINs: the role of ARF6.Exploitation of the ability of γ-tocopherol to facilitate membrane co-localization of Akt and PHLPP1 to develop PHLPP1-targeted Akt inhibitors 53BP1 suppresses tumor growth and promotes susceptibility to apoptosis of ovarian cancer cells through modulation of the Akt pathway Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion Accurate prediction of the bound form of the Akt pleckstrin homology domain using normal mode analysis to explore structural flexibility High-throughput fluorescence assay for membrane-protein interaction PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3 for polyphosphoinositide-binding domains.Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma.Sirolimus and metformin synergistically inhibit hepatocellular carcinoma cell proliferation and improve long-term survival in patients with HCC related to hepatitis B virus induced cirrhosis after liver transplantation.AKT/GSK3β Signaling in Glioblastoma.PI3K/AKT/mTOR signaling pathway as a therapeutic target for ovarian cancer.Mice Deficient in lysophosphatidic acid acyltransferase delta (Lpaatδ)/acylglycerophosphate acyltransferase 4 (Agpat4) Have Impaired Learning and Memory.A protocol for the systematic and quantitative measurement of protein-lipid interactions using the liposome-microarray-based assay.Combination Nanopreparations of a Novel Proapoptotic Drug - NCL-240, TRAIL and siRNA.

P2860

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P2860

Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.

http://www.wikidata.org/entity/Q33735612

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Small molecule inhibition of p ...... o pleckstrin homology domains.

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Small molecule inhibition of p ...... o pleckstrin homology domains.

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type

label

Small molecule inhibition of p ...... o pleckstrin homology domains.

@ast

Small molecule inhibition of p ...... o pleckstrin homology domains.

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prefLabel

Small molecule inhibition of p ...... o pleckstrin homology domains.

@ast

Small molecule inhibition of p ...... o pleckstrin homology domains.

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P1433

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P356

PNAS.1004522107

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Small molecule inhibition of p ...... o pleckstrin homology domains.

@en

P2093

Alexey Lugovskoy

http://www.w3.org/2001/XMLSchema#string

Benchun Miao

http://www.w3.org/2001/XMLSchema#string

Brian Schaffhausen

http://www.w3.org/2001/XMLSchema#string

C V Ramana

http://www.w3.org/2001/XMLSchema#string

Gerhard Wagner

http://www.w3.org/2001/XMLSchema#string

Igor Skidan

http://www.w3.org/2001/XMLSchema#string

Jenny Maki

http://www.w3.org/2001/XMLSchema#string

Jinsheng Yang

http://www.w3.org/2001/XMLSchema#string

Junying Yuan

http://www.w3.org/2001/XMLSchema#string

Kai Long

http://www.w3.org/2001/XMLSchema#string

P2860

TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor

Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

Solution structure and backbone dynamics of the pleckstrin homology domain of the human protein kinase B (PKB/Akt). Interaction with inositol phosphates

The phosphoinositide 3-kinase pathway

The complexity of TNF-related apoptosis-inducing ligand

Cellular survival: a play in three Akts

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

Membrane recognition by phospholipid-binding domains

PI3K pathway alterations in cancer: variations on a theme

P304

20126-20131

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P31

scholarly article

P356

10.1073/PNAS.1004522107

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P433

46

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P478

107

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P50

Alexei Degterev

P577

2010-11-01T00:00:00Z

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P5875

47644920

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21041639

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P932

2993381

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