The type I insulin-like growth factor receptor regulates cancer metastasis independently of primary tumor growth by promoting invasion and survival.
about
Targeting insulin and insulin-like growth factor signaling in breast cancerTargeting the insulin-like growth factor pathway in hepatocellular carcinomaSWIFT MRI enhances detection of breast cancer metastasis to the lungOptical imaging probes in oncologySustained proliferation in cancer: Mechanisms and novel therapeutic targetsAnoikis resistance: an essential prerequisite for tumor metastasisInhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasis.Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells.Northwestern profiling of potential translation-regulatory proteins in human breast epithelial cells and malignant breast tissues: evidence for pathological activation of the IGF1R IRES.Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231Evaluation of a novel hexavalent humanized anti-IGF-1R antibody and its bivalent parental IgG in diverse cancer cell linesHuman GH receptor-IGF-1 receptor interaction: implications for GH signaling.Targeting 3-phosphoinoside-dependent kinase-1 to inhibit insulin-like growth factor-I induced AKT and p70 S6 kinase activation in breast cancer cells.The effects of type 1 IGF receptor inhibition in a mouse model of diabetic kidney disease.The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models.Extracellular molecules involved in cancer cell invasionElevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes.The Role of the Insulin/IGF System in Cancer: Lessons Learned from Clinical Trials and the Energy Balance-Cancer Link.Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells.Effect of ulinastatin on growth inhibition, apoptosis of breast carcinoma cells is related to a decrease in signal conduction of JNk-2 and NF-κB.Suppression of Homologous Recombination by insulin-like growth factor-1 inhibition sensitizes cancer cells to PARP inhibitorsTargeting the insulin growth factor and the vascular endothelial growth factor pathways in ovarian cancer.Enhancement of doxorubicin cytotoxicity of human cancer cells by tyrosine kinase inhibition of insulin receptor and type I IGF receptorPleckstrin homology domain-interacting protein (PHIP) as a marker and mediator of melanoma metastasis.Insulin-like growth factors are essential to prevent anoikis in oestrogen-responsive breast cancer cells: importance of the type I IGF receptor and PI3-kinase/Akt pathwayPhase I study of humanized monoclonal antibody AVE1642 directed against the type 1 insulin-like growth factor receptor (IGF-1R), administered in combination with anticancer therapies to patients with advanced solid tumors.Insulin-like growth factor: current concepts and new developments in cancer therapy.The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer.Type I insulin-like growth factor receptor signaling in hematological malignancies.Biology and significance of circulating and disseminated tumour cells in colorectal cancer.The decline and fall of the IGF-I receptor.Insulin and IGFs in obesity-related breast cancer.Minireview: Were the IGF Signaling Inhibitors All Bad?Molecular insights into tumour metastasis: tracing the dominant events.Recent development of targeted approaches for the treatment of breast cancer.Plasticity of tumor cell invasion: governance by growth factors and cytokines.Inhibition of IGF-IR increases chemosensitivity in human colorectal cancer cells through MRP-2 promoter suppression.Generation of a conditionally transformed murine embryonic fibroblast cell line using doxycycline-dependent IGF-1R overexpression.The emerging role of insulin-like growth factor 1 receptor (IGF1r) in gastrointestinal stromal tumors (GISTs).Methylation profiling in individuals with uniparental disomy identifies novel differentially methylated regions on chromosome 15
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P2860
The type I insulin-like growth factor receptor regulates cancer metastasis independently of primary tumor growth by promoting invasion and survival.
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The type I insulin-like growth ...... omoting invasion and survival.
@ast
The type I insulin-like growth ...... omoting invasion and survival.
@en
type
label
The type I insulin-like growth ...... omoting invasion and survival.
@ast
The type I insulin-like growth ...... omoting invasion and survival.
@en
prefLabel
The type I insulin-like growth ...... omoting invasion and survival.
@ast
The type I insulin-like growth ...... omoting invasion and survival.
@en
P2093
P2860
P356
P1433
P1476
The type I insulin-like growth ...... romoting invasion and survival
@en
P2093
M Gaillard-Kelly
P2860
P2888
P304
P356
10.1038/ONC.2009.316
P407
P50
P577
2009-10-19T00:00:00Z
P5875
P6179
1041401170