mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome. - Wikidata - awgldk - TriplyDB

mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.

mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.

http://www.wikidata.org/entity/Q33749391

about

Mitochondrial disorders in children: toward development of small-molecule treatment strategies The neurology of mTOR The two-hit hypothesis for neuroinflammation: role of exogenous ATP in modulating inflammation in the brain Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron-sulfur protein Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin Exploring new pathways of neurodegeneration in ALS: the role of mitochondria quality control Mitochondrial complex I deficiency leads to inflammation and retinal ganglion cell death in the Ndufs4 mouse Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration.Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression.The mitochondrial unfolded protein response and increased longevity: cause, consequence, or correlation?Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome.Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration.Circadian clock: linking epigenetics to aging.From rapalogs to anti-aging formula.In silico investigation of potential mTOR inhibitors from traditional Chinese medicine for treatment of Leigh syndrome Mitochondrial complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation.PARP inhibition delays progression of mitochondrial encephalopathy in mice.Mitochondria are required for pro-ageing features of the senescent phenotype.Glycerol extends lifespan of Brachionus manjavacas (Rotifera) and protects against stressors Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function.Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3 Metabolic control of autophagy Rapamycin-induced metabolic defects are reversible in both lean and obese mice Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice.Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders.Gerosuppression in confluent cells.Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion.Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure.MTO1 mediates tissue specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention.Rapamycin and chloroquine: the in vitro and in vivo effects of autophagy-modifying drugs show promising results in valosin containing protein multisystem proteinopathy.Rapamycin and ageing: when, for how long, and how much?Cell-permeable protein therapy for complex I dysfunction Opa1 overexpression ameliorates the phenotype of two mitochondrial disease mouse models.Potential compounds for the treatment of mitochondrial disease.Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice Reduced Glucose Sensation Can Increase the Fitness of Saccharomyces cerevisiae Lacking Mitochondrial DNA.Mitochondrial Diseases Part III: Therapeutic interventions in mouse models of OXPHOS deficiencies.Region-Specific Defects of Respiratory Capacities in the Ndufs4(KO) Mouse Brain

P2860

Q26767327-E542B9F3-6F64-4484-9A4A-9C6252952359 Q26824286-A1A4E413-FA57-49EC-BB3D-9218FD004579 Q26824833-9B74CCB1-DC93-4427-835A-BD3DE0A1F04B Q27321453-0752F1C3-4760-4D4B-94E3-59CBC878E78C Q28274227-938CBFB1-754A-4ACF-850D-F759F02AF8F0 Q28307873-F4558016-1595-43D2-B06B-A69EDD34D38A Q28391199-D712CAB3-428C-4D29-AAE7-A9CC7AC8A7F6 Q28392327-6B071ED2-5281-434D-A0AF-0FA9C9782B82 Q28834138-BDFA1397-4F0F-4F53-98CE-35F554ABC810 Q33603263-D1C75486-0A51-49FD-B7F9-C6ED7DD78FB1 Q33649447-1F6362B5-F605-4B2B-B3D5-6328F25BFFD0 Q33723766-5CC99519-E279-4A75-9E99-3925BB344155 Q33737837-DF7CAF93-5BE1-4118-8887-2F2696234CC5 Q33801201-20ACA31C-D6AD-4EF1-9616-F71B8F2D3D31 Q33803472-FE87D1AB-E3EB-4C23-87D5-190C6AC25682 Q33829205-EEC5642C-B085-4D3A-A5E2-6FA63F044124 Q33876312-7F4427D7-AEA1-45CF-822B-0E1861CAEFC2 Q33931142-72BF5D73-5634-4431-8184-4EB4358C91A0 Q34000773-6132D33C-3DC6-452D-80F9-2B5D9056B4F2 Q34046100-8C2C81A7-9EC9-4590-AF5E-D4E1F822761C Q34112022-3D958FE4-884A-4360-9AD5-9B857540BD1A Q34170669-1983C174-2448-49E6-A977-340909C8B1CD Q34372265-04E8FF8D-D43D-4FA2-8947-2EFDA7304CE2 Q34452291-14A97102-942E-4241-A962-D9EC8F7FAE0B Q34461128-B05D2C26-82A8-4A23-BED1-22D4BEE60EF9 Q34802375-C09AABA0-DCE2-472B-A289-B976314713DE Q34836208-3A291FB5-AF74-4F78-B697-3D0379BAFD01 Q34982499-E75124BE-9DCC-4FD0-9DF8-B329FFCFB3C7 Q35149607-6A3B4728-B10C-4570-8515-18D4017BA22B Q35192445-8D8F261E-5AF3-41A1-92A8-6A75CAA95EE6 Q35234097-12A8702E-98F0-424D-8309-C7E45721747B Q35462835-E9ADF840-1452-43BC-AA9B-84F611D01476 Q35468262-28CDFE69-1944-466A-8D1B-A277853FBFA0 Q35660914-CFD98313-AEF2-4E8F-8FAF-37A7AC9C2FFF Q35689631-6B4A84EF-7913-4159-998B-0479165688D3 Q35847813-A6FE5CC4-BE81-4700-8358-8BE81DF2DD55 Q35877085-00256BD8-465D-47A7-8067-34CE8A40148B Q35890030-4F21CBA3-1150-4CAE-AF59-516F3C1EDFED Q35893619-6CDFB970-6131-4BC3-9479-63B498DEA112 Q35908395-71235E42-7C0D-4C1A-B568-0B0F446D698A

P2860

mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.

http://www.wikidata.org/entity/Q33749391

description

2013 nî lūn-bûn

@nan

2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.

@ast

mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.

@en

type

label

mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.

@ast

mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.

@en

prefLabel

mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.

@ast

mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.

@en

P1433

Q33749391-72BC705B-2FCE-424B-9888-3D9BE7616C87

P1476

Q33749391-1048FF4A-7D7B-487C-8052-F5F4522888D9

P2093

Q33749391-0359D8F2-6379-49A1-A97B-1E7D958E4536

Q33749391-07AE3F6E-9B10-4D30-BFF1-3899FBE3FD05

Q33749391-22900C0E-7E3C-4E42-B580-745F53688E02

Q33749391-44881B27-410F-4501-9162-9605841B278D

Q33749391-630DFD57-DA7D-4399-9418-201257E17D60

Q33749391-97925031-4940-4F7F-9A4C-BBF729FA1FDB

Q33749391-98F6A092-A8B8-44F8-8EF8-4B231461F57E

Q33749391-A468B326-23BE-4737-B2A4-D197F6579B83

Q33749391-B0F873E3-C80B-4072-9885-E2A462E0DFB5

Q33749391-BCBC560F-30E1-4A26-8F63-3877471D6A78

P2860

Q33749391-2153189B-D71D-48AA-B86C-537FB8745915

Q33749391-3B5D2F67-10E9-4230-84ED-75E89DA818AE

Q33749391-43BCBC67-B656-4677-AEE7-98188D92B4FC

Q33749391-630BB063-E708-4E22-A3D2-6E97B4E3B030

Q33749391-6B9CDA81-167B-4717-A54A-A49412FFB48E

Q33749391-77AAC08D-CD57-4908-95EA-43B2E06DF49F

Q33749391-83771420-C53F-4E58-9F72-B39621A059FB

Q33749391-9FF5F7AA-18A0-49D2-A48F-0819480BC362

Q33749391-A44D7626-C422-4AAE-A0C2-7183F7EA5202

Q33749391-C806E7FE-51CC-4003-9A39-2AD9782441BD

P304

Q33749391-62624E23-E015-4E09-A4E6-A30211B848F3

P31

Q33749391-F6CC7E2E-044B-4D77-AB42-5903E4DD518E

P356

Q33749391-2A141AB4-0805-4DB9-AC7A-8D81E5A6830F

P407

Q33749391-E4185435-F26D-469F-A77B-F813AD8D7384

P433

Q33749391-530B1C1C-60F1-4600-B628-86B3D578D7AC

P478

Q33749391-61E80877-710F-417D-9EF0-6FE29DFEE42B

P50

Q33749391-0A98FEFE-5109-49F8-8071-70A376FE41E9

Q33749391-BBCE96A7-7374-4E93-B873-973C52FE8A03

Q33749391-D7D1966E-BF40-4CD5-B022-302F0CE6DA14

Q33749391-E495F1A9-0485-4A62-BB86-F27C871011FE

P577

Q33749391-5D2F0F25-3FAB-4C30-942C-0B3EE3089575

P5875

Q33749391-6660DAB8-6B05-40C6-804F-C4679BDF849F

P698

Q33749391-66F441DD-C458-431A-8372-4703CBEBB56E

P932

Q33749391-FA6C689C-05C7-48A4-81B5-17965D61CDF2

P356

SCIENCE.1244360

P1433

P1476

mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.

@en

P2093

Arni Gagnidze

http://www.w3.org/2001/XMLSchema#string

Brian M Wasko

http://www.w3.org/2001/XMLSchema#string

Ernst-Bernhard Kayser

http://www.w3.org/2001/XMLSchema#string

Fresnida J Ramos

http://www.w3.org/2001/XMLSchema#string

Jessica Hui

http://www.w3.org/2001/XMLSchema#string

Kelly Oh

http://www.w3.org/2001/XMLSchema#string

Margaret M Sedensky

http://www.w3.org/2001/XMLSchema#string

Maya Sangesland

http://www.w3.org/2001/XMLSchema#string

Melana E Yanos

http://www.w3.org/2001/XMLSchema#string

Peter S Rabinovitch

http://www.w3.org/2001/XMLSchema#string

P2860

mTOR is a key modulator of ageing and age-related disease

mTOR signaling in growth control and disease

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

cAMP-dependent phosphorylation of the nuclear encoded 18-kDa (IP) subunit of respiratory complex I and activation of the complex in serum-starved mouse fibroblast cultures

Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy.

Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome.

Calorie restriction: decelerating mTOR-driven aging from cells to organisms (including humans).

The incidence of mitochondrial encephalomyopathies in childhood: clinical features and morphological, biochemical, and DNA abnormalities.

Immunosuppressive agents in solid organ transplantation: Mechanisms of action and therapeutic efficacy.

Leigh syndrome, a mitochondrial encephalo(myo)pathy. A review of the literature.

P304

1524-1528

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1126/SCIENCE.1244360

http://www.w3.org/2001/XMLSchema#string

P407

P433

6165

http://www.w3.org/2001/XMLSchema#string

P478

342

http://www.w3.org/2001/XMLSchema#string

P50

Anthony S Castanza

Albert Quintana

Lauren Zebertavage

Matt Kaeberlein

P577

2013-11-14T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

258527381

http://www.w3.org/2001/XMLSchema#string

P698

24231806

http://www.w3.org/2001/XMLSchema#string

P932

4055856

http://www.w3.org/2001/XMLSchema#string