Distinct pose of discodermolide in taxol binding pocket drives a complementary mode of microtubule stabilization.
about
Microtubule-stabilizing drugs from marine sponges: focus on peloruside A and zampanolideDesign and synthesis of (+)-discodermolide-paclitaxel hybrids leading to enhanced biological activityA selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation.Structural evidence for cooperative microtubule stabilization by Taxol and the endogenous dynamics regulator MAP4.2-(m-Azidobenzoyl)taxol binds differentially to distinct β-tubulin isotypesTaccalonolide binding to tubulin imparts microtubule stability and potent in vivo activity.The Lithistida: important sources of compounds useful in biomedical research.Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities.Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration.Structural Basis of Microtubule Stabilization by Discodermolide.Design, synthesis and biological evaluation of a simplified fluorescently labeled discodermolide as a molecular probe to study the binding of discodermolide to tubulin.Synergistic interactions between peloruside A and other microtubule-stabilizing and destabilizing agents in cultured human ovarian carcinoma cells and murine T cells.Taxol®: The First Microtubule Stabilizing Agent.Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: implications for chemotherapy-induced peripheral neuropathy.Improved Dose-Response Relationship of (+)-Discodermolide-Taxol Hybrid Congeners.Repositioning Microtubule Stabilizing Drugs for Brain Disorders
P2860
Q33837001-A7E7993E-3E80-4158-AE4C-27B90C45F87BQ34003701-F1558628-902C-49BB-9C43-3949348554C7Q34089593-030844D3-E671-484A-ACD2-4865A24A5EE3Q34719865-AD5B2189-DA5A-40C0-A7ED-842ADB9FD6BFQ37244057-7224FA3E-C4DF-48B9-AC4D-7F1F03F18F70Q37323043-CBC643D3-3A2C-4F75-BDAC-3A4F182388D0Q37339521-B29F21F7-FA99-498D-929E-D329FDC78759Q37802696-821D2EE5-1974-40A2-9E3A-3F1228210755Q38047388-AF2456BE-2791-41A1-BCDA-CC8167A81608Q38183686-BD27BB2E-DFDD-4F36-BDED-8855B33CD8DDQ38705087-8E228BEA-6BE0-428B-8C80-686035C263CEQ38957234-14A73992-4D69-4601-A1DE-0A32B9F99B51Q39498092-C4B9F575-B2F9-4699-B94A-4514926457E4Q39654810-4673E1A4-8862-44D7-B831-D972580965EBQ41573963-578BA142-1599-46A5-946F-9369EF9321B6Q42112858-7C248D32-AA9B-4EB1-A5C4-D885B8B892E9Q55417605-B1DC4364-3949-46F9-A226-F7ECF2C5EEDCQ58795487-0F7E5588-E6B8-4990-9BE4-CDC6E85B3779
P2860
Distinct pose of discodermolide in taxol binding pocket drives a complementary mode of microtubule stabilization.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Distinct pose of discodermolid ...... of microtubule stabilization.
@ast
Distinct pose of discodermolid ...... of microtubule stabilization.
@en
type
label
Distinct pose of discodermolid ...... of microtubule stabilization.
@ast
Distinct pose of discodermolid ...... of microtubule stabilization.
@en
prefLabel
Distinct pose of discodermolid ...... of microtubule stabilization.
@ast
Distinct pose of discodermolid ...... of microtubule stabilization.
@en
P2860
P50
P356
P1433
P1476
Distinct pose of discodermolid ...... of microtubule stabilization.
@en
P2860
P304
11664-11677
P356
10.1021/BI901351Q
P4011
9a0eee445494a2326dbab04003557adc05f367b9
P407
P50
P577
2009-12-01T00:00:00Z