Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression
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Role of cerebral cortex in the neuropathology of Huntington's diseaseTransgenic animal models for study of the pathogenesis of Huntington's disease and therapyMouse models of polyglutamine diseases: review and data table. Part ILaquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease.Effects of deletion of mutant huntingtin in steroidogenic factor 1 neurons on the psychiatric and metabolic phenotype in the BACHD mouse model of Huntington diseaseSex-dependent changes in social behaviors in motor pre-symptomatic R6/1 mice.The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signalling.A fully humanized transgenic mouse model of Huntington disease.microRNA-128a dysregulation in transgenic Huntington's disease monkeys.Reducing Igf-1r levels leads to paradoxical and sexually dimorphic effects in HD mice.Neuroprotective properties of cannabigerol in Huntington's disease: studies in R6/2 mice and 3-nitropropionate-lesioned mice.Increased Body Weight of the BAC HD Transgenic Mouse Model of Huntington's Disease Accounts for Some but Not All of the Observed HD-like Motor Deficits.IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington diseaseNeurodegenerative processes in Huntington's disease.Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease.Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington's disease: role of CB1 and CB2 receptors.Hypothalamic overexpression of mutant huntingtin causes dysregulation of brown adipose tissue.Cross-phenotype association tests uncover genes mediating nutrient response in Drosophila.Novel BAC Mouse Model of Huntington's Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype.Expression of mutant huntingtin in leptin receptor-expressing neurons does not control the metabolic and psychiatric phenotype of the BACHD mouseProtection by dietary restriction in the YAC128 mouse model of Huntington's disease: Relation to genes regulating histone acetylation and HTT.Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease.Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis.Screening of therapeutic strategies for Huntington's disease in YAC128 transgenic mice.Hypothalamic alterations in Huntington's disease patients: comparison with genetic rodent models.Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.Cognitive dysfunction in Huntington's disease: mechanisms and therapeutic strategies beyond BDNF.Activation of IGF-1 and insulin signaling pathways ameliorate mitochondrial function and energy metabolism in Huntington's Disease human lymphoblasts.Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic mice.Single-cell suspension methodology favors survival and vascularization of fetal striatal grafts in the YAC128 mouse model of Huntington's disease.IGF-1 intranasal administration rescues Huntington's disease phenotypes in YAC128 mice.Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington's disease.Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice.Manganese and the Insulin-IGF Signaling Network in Huntington's Disease and Other Neurodegenerative Disorders.Hypothalamic Alterations in Neurodegenerative Diseases and Their Relation to Abnormal Energy Metabolism.Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease.
P2860
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P2860
Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Full-length huntingtin levels ...... ike growth factor 1 expression
@ast
Full-length huntingtin levels ...... ike growth factor 1 expression
@en
type
label
Full-length huntingtin levels ...... ike growth factor 1 expression
@ast
Full-length huntingtin levels ...... ike growth factor 1 expression
@en
prefLabel
Full-length huntingtin levels ...... ike growth factor 1 expression
@ast
Full-length huntingtin levels ...... ike growth factor 1 expression
@en
P2093
P2860
P50
P356
P1476
Full-length huntingtin levels ...... ike growth factor 1 expression
@en
P2093
Jeong Eun Kim
Nagat Bissada
Robert M Friedlander
Rona K Graham
X William Yang
Yuanyun Xie
P2860
P304
P356
10.1093/HMG/DDQ026
P577
2010-01-22T00:00:00Z