Atomistic simulations of the effects of polyglutamine chain length and solvent quality on conformational equilibria and spontaneous homodimerization
about
Residual structure in unfolded proteinsA condensation-ordering mechanism in nanoparticle-catalyzed peptide aggregation.Secondary Structure of Huntingtin Amino-Terminal RegionA decade and a half of protein intrinsic disorder: biology still waits for physicsDopamine-induced α-synuclein oligomers show self- and cross-propagation properties.Understanding protein non-folding.Elongation kinetics of polyglutamine peptide fibrils: a quartz crystal microbalance with dissipation study.Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment.Improved atomistic Monte Carlo simulations demonstrate that poly-L-proline adopts heterogeneous ensembles of conformations of semi-rigid segments interrupted by kinks.Model discrimination and mechanistic interpretation of kinetic data in protein aggregation studies.Methods for Monte Carlo simulations of biomacromoleculesDescribing sequence-ensemble relationships for intrinsically disordered proteins.Polyglutamine induced misfolding of huntingtin exon1 is modulated by the flanking sequences.Net charge per residue modulates conformational ensembles of intrinsically disordered proteinsA coarse-grained model for polyglutamine aggregation modulated by amphipathic flanking sequencesAssessing the contribution of heterogeneous distributions of oligomers to aggregation mechanisms of polyglutamine peptidesAre long-range structural correlations behind the aggregration phenomena of polyglutamine diseases?Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome.Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes.Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins.Aggregation kinetics of interrupted polyglutamine peptidesThe intrinsically disordered regions of the Drosophila melanogaster Hox protein ultrabithorax select interacting proteins based on partner topology.Role of water in protein aggregation and amyloid polymorphism.Amyloids go genomic: insights regarding the sequence determinants of prion formation from genome-wide studies.Sequence-dependent stability test of a left-handed β-helix motif.Scaling properties of glycine-rich sequences in guanidine hydrochloride solutions.Anti-PolyQ Antibodies Recognize a Short PolyQ Stretch in Both Normal and Mutant Huntingtin Exon 1.Structural transitions and oligomerization along polyalanine fibril formation pathways from computer simulationsFolding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.An Analysis of Biomolecular Force Fields for Simulations of Polyglutamine in SolutionThe emerging role of the first 17 amino acids of huntingtin in Huntington's diseaseConformational properties of polyglutamine sequences in guanidine hydrochloride solutionsA quantitative measure for protein conformational heterogeneityThermodynamics of beta-sheet formation in polyglutamineSingle homopolypeptide chains collapse into mechanically rigid conformations.Comparative analysis of anti-polyglutamine Fab crystals grown on Earth and in microgravity.Examining polyglutamine peptide length: a connection between collapsed conformations and increased aggregation.Finding order within disorder: elucidating the structure of proteins associated with neurodegenerative disease.Physical chemistry of polyglutamine: intriguing tales of a monotonous sequence.Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative Disease.
P2860
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P2860
Atomistic simulations of the effects of polyglutamine chain length and solvent quality on conformational equilibria and spontaneous homodimerization
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Atomistic simulations of the e ...... d spontaneous homodimerization
@ast
Atomistic simulations of the e ...... d spontaneous homodimerization
@en
type
label
Atomistic simulations of the e ...... d spontaneous homodimerization
@ast
Atomistic simulations of the e ...... d spontaneous homodimerization
@en
prefLabel
Atomistic simulations of the e ...... d spontaneous homodimerization
@ast
Atomistic simulations of the e ...... d spontaneous homodimerization
@en
P2093
P2860
P1476
Atomistic simulations of the e ...... d spontaneous homodimerization
@en
P2093
Andreas Vitalis
Rohit V Pappu
Xiaoling Wang
P2860
P304
P356
10.1016/J.JMB.2008.09.026
P577
2008-09-18T00:00:00Z