Antibody remodeling: a general solution to the design of a metal-coordination site in an antibody binding pocket
about
Emerging critical roles of Fe-S clusters in DNA replication and repair.Definite coordination arrangement of organometallic palladium complexes accumulated on the designed interior surface of apo-ferritinStructural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding siteStructure-assisted redesign of a protein-zinc-binding site with femtomolar affinityOptGraft: A computational procedure for transferring a binding site onto an existing protein scaffold.Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigenA cofactor approach to copper-dependent catalytic antibodiesInterfacial metal and antibody recognitionScorpion toxins as natural scaffolds for protein engineering2D IR spectroscopy of histidine: probing side-chain structure and dynamics via backbone amide vibrations.Dissection of an antibody-catalyzed reaction.A complementarity-determining region synthetic peptide acts as a miniantibody and neutralizes human immunodeficiency virus type 1 in vitro.Direct selection of antibodies that coordinate metals from semisynthetic combinatorial libraries.Defining antibody-antigen recognition: towards engineered antibodies and epitopes.Medical applications of single-chain antibodies.Selection of carbonic anhydrase variants displayed on phage. Aromatic residues in zinc binding site enhance metal affinity and equilibration kinetics.Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding.On the failure of de novo-designed peptides as biocatalysts.Monoclonal antibodies specific for mercuric ions.Enhancement and destruction of antibody function by somatic mutation: unequal occurrence is controlled by V gene combinatorial associations.Staphylococcal enterotoxin A has two cooperative binding sites on major histocompatibility complex class II.Antigen recognition and targeted delivery by the single-chain Fv.A metalloantibody that irreversibly binds a protein antigen.Construction of a high affinity zinc switch in the kappa-opioid receptor.Coordination chemistry of iron(III)-porphyrin-antibody complexes.The intrinsic cysteine and histidine residues of the anti-Salmonella antibody Se155-4: a model for the introduction of new functions into antibody-binding sites.From "hemoabzymes" to "hemozymes": towards new biocatalysts for selective oxidations.Robust Production, Crystallization, Structure Determination, and Analysis of [Fe-S] Proteins: Uncovering Control of Electron Shuttling and Gating in the Respiratory Metabolism of Molybdopterin Guanine Dinucleotide Enzymes.Various strategies for obtaining oxidative artificial hemoproteins with a catalytic oxidative activity: from "Hemoabzymes" to "Hemozymes"?
P2860
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P2860
Antibody remodeling: a general solution to the design of a metal-coordination site in an antibody binding pocket
description
1990 nî lūn-bûn
@nan
1990 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Antibody remodeling: a general ...... in an antibody binding pocket
@ast
Antibody remodeling: a general ...... in an antibody binding pocket
@en
type
label
Antibody remodeling: a general ...... in an antibody binding pocket
@ast
Antibody remodeling: a general ...... in an antibody binding pocket
@en
prefLabel
Antibody remodeling: a general ...... in an antibody binding pocket
@ast
Antibody remodeling: a general ...... in an antibody binding pocket
@en
P2093
P2860
P356
P1476
Antibody remodeling: a general ...... in an antibody binding pocket
@en
P2093
B L Iverson
E D Getzoff
R A Lerner
S A Iverson
S J Benkovic
V A Roberts
P2860
P304
P356
10.1073/PNAS.87.17.6654
P407
P577
1990-09-01T00:00:00Z