Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity. - Wikidata - awgldk - TriplyDB

Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity.

Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity.

http://www.wikidata.org/entity/Q33771413

about

Chronic lymphocytic leukaemia: an overview of aetiology in light of recent developments in classification and pathogenesis PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL)Targeting the B-cell receptor signaling pathway in B lymphoid malignancies The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy Immunological aspects in chronic lymphocytic leukemia (CLL) development B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells Functional and prognostic role of ZAP-70 in chronic lymphocytic leukaemia Lipoprotein lipase in chronic lymphocytic leukemia: function and prognostic implications.Stereotypical chronic lymphocytic leukemia B-cell receptors recognize survival promoting antigens on stromal cells.Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities.Chronic lymphocytic leukemia and autoimmunity: a systematic review.Characterization of structurally defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells.Single-cell analysis reveals oligoclonality among 'low-count' monoclonal B-cell lymphocytosis Somatic hypermutations confer rheumatoid factor activity in hepatitis C virus-associated mixed cryoglobulinemia TLR9 Ligand (CpG Oligodeoxynucleotide) Induces CLL B-Cells to Differentiate into CD20(+) Antibody-Secreting Cells.Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin B-cell receptor epitope recognition correlates with the clinical course of chronic lymphocytic leukemia.High-density screening reveals a different spectrum of genomic aberrations in chronic lymphocytic leukemia patients with 'stereotyped' IGHV3-21 and IGHV4-34 B-cell receptors.Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases.Distinct gene expression profiles in subsets of chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors.A flow cytometry-based strategy to identify and express IgM from VH1-69+ clonal peripheral B cells.Therapeutic implications of variable expression of CD52 on clonal cytotoxic T cells in CD8+ large granular lymphocyte leukemia Anticipation in families with chronic lymphocytic leukemia and other lymphoproliferative disorders.B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia Peptides that bind specifically to an antibody from a chronic lymphocytic leukemia clone expressing unmutated immunoglobulin variable region genes.IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria.Intraclonal cell expansion and selection driven by B cell receptor in chronic lymphocytic leukemia.Two types of BCR interactions are positively selected during leukemia development in the Eμ-TCL1 transgenic mouse model of CLL.Immunoglobulin transcript sequence and somatic hypermutation computation from unselected RNA-seq reads in chronic lymphocytic leukemia.An entity evolving into a community: defining the common ancestor and evolutionary trajectory of chronic lymphocytic leukemia stereotyped subset #4.Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification.Similarities and differences between the light and heavy chain Ig variable region gene repertoires in chronic lymphocytic leukemia.Excessive antigen reactivity may underlie the clinical aggressiveness of chronic lymphocytic leukemia stereotyped subset #8.Autoreactivity in human IgG+ memory B cells.Enhanced outgrowth of EBV-transformed chronic lymphocytic leukemia B cells mediated by coculture with macrophage feeder cells.TLR-9 and IL-15 Synergy Promotes the In Vitro Clonal Expansion of Chronic Lymphocytic Leukemia B Cells.Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT.Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies.A checkpoint for autoreactivity in human IgM+ memory B cell development

P2860

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P2860

Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity.

http://www.wikidata.org/entity/Q33771413

description

2005 nî lūn-bûn

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2005 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի մայիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Unmutated and mutated chronic ...... different antibody reactivity.

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Unmutated and mutated chronic ...... different antibody reactivity.

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type

label

Unmutated and mutated chronic ...... different antibody reactivity.

@ast

Unmutated and mutated chronic ...... different antibody reactivity.

@en

prefLabel

Unmutated and mutated chronic ...... different antibody reactivity.

@ast

Unmutated and mutated chronic ...... different antibody reactivity.

@en

P1433

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P1433

Journal of Clinical Investigation

P1476

Unmutated and mutated chronic ...... different antibody reactivity.

@en

P2093

Bradley T Messmer

http://www.w3.org/2001/XMLSchema#string

Emilia Albesiano

http://www.w3.org/2001/XMLSchema#string

Eric Meffre

http://www.w3.org/2001/XMLSchema#string

Hedda Wardemann

http://www.w3.org/2001/XMLSchema#string

Kai Xu

http://www.w3.org/2001/XMLSchema#string

Maxime Hervé

http://www.w3.org/2001/XMLSchema#string

Nicholas Chiorazzi

http://www.w3.org/2001/XMLSchema#string

Yen-Shing Ng

http://www.w3.org/2001/XMLSchema#string

P2860

Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

Marginal-zone B cells

Chronic lymphocytic leukemia

Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia

Predominant autoantibody production by early human B cell precursors

In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells

Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia.

Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.

Development and function of B-1 cells.

Antibody regulation of B cell development.

P304

1636-1643

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scholarly article

P356

10.1172/JCI24387

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P433

6

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P478

115

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P577

2005-05-02T00:00:00Z

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P698

15902303

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P921

P932

1088018

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