CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease. - Wikidata - awgldk - TriplyDB

CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease.

CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease.

http://www.wikidata.org/entity/Q33773689

about

Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's disease Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation Striatal Vulnerability in Huntington's Disease: Neuroprotection Versus Neurotoxicity.The emerging role of guanine nucleotide exchange factors in ALS and other neurodegenerative diseases.Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons Basal Ganglia disorders associated with imbalances in the striatal striosome and matrix compartments.Huntington's disease, calcium, and mitochondria.Ras guanyl nucleotide releasing protein 2 affects cell viability and cell-matrix adhesion in ECV304 endothelial cells.Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements.Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract.Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease.Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay.Development of repetitive behavior in a mouse model: roles of indirect and striosomal basal ganglia pathways.Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition

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P2860

CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease.

http://www.wikidata.org/entity/Q33773689

description

2010 nî lūn-bûn

@nan

2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

CalDAG-GEFI down-regulation in ...... hange in Huntington's disease.

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CalDAG-GEFI down-regulation in ...... hange in Huntington's disease.

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CalDAG-GEFI down-regulation in ...... hange in Huntington's disease.

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CalDAG-GEFI down-regulation in ...... hange in Huntington's disease.

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Human Molecular Genetics

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CalDAG-GEFI down-regulation in ...... hange in Huntington's disease.

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Ann M Graybiel

http://www.w3.org/2001/XMLSchema#string

Anna E Borkowska

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Ben Woodman

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David E Housman

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Denise E Dunn

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Donald C Lo

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Jill R Crittenden

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Matthew P Frosch

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Michael Yim

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P2860

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia

Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation

A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2

Guanine nucleotide exchange factors CalDAG-GEFI and CalDAG-GEFII are colocalized in striatal projection neurons

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

A gene expression atlas of the central nervous system based on bacterial artificial chromosomes

P304

1756-1765

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scholarly article

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10.1093/HMG/DDQ055

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9

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19

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Farhan I Merali

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2010-02-10T00:00:00Z

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41421703

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20147317

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P921

corpus striatum

Huntington disease

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2850620

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