Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78 - Wikidata - awgldk - TriplyDB

Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78

Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78

http://www.wikidata.org/entity/Q33778232

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Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP)Pharmacoperones: a new therapeutic approach for diseases caused by misfolded G protein-coupled receptors A comprehensive review of retinal gene therapy Defining the catalytic activity of nanoceria in the P23H-1 rat, a photoreceptor degeneration model Ablation of C/EBP homologous protein does not protect T17M RHO mice from retinal degeneration Inactivation of VCP/ter94 suppresses retinal pathology caused by misfolded rhodopsin in Drosophila Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa ER stress and apoptosis: a new mechanism for retinal cell death.Pharmacological modulation of the retinal unfolded protein response in Bardet-Biedl syndrome reduces apoptosis and preserves light detection ability Potential of Small Molecule-Mediated Reprogramming of Rod Photoreceptors to Treat Retinitis Pigmentosa Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity Hearing impairment in the P23H-1 retinal degeneration rat model.The human rhodopsin kinase promoter in an AAV5 vector confers rod- and cone-specific expression in the primate retina.The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa.Modulation of cellular signaling pathways in P23H rhodopsin photoreceptors.Modulation of the rate of retinal degeneration in T17M RHO mice by reprogramming the unfolded protein response.Chaperoning G protein-coupled receptors: from cell biology to therapeutics Endoplasmic reticulum stress and the unfolded protein responses in retinal degeneration.Gene augmentation for adRP mutations in RHO.Suppression and replacement gene therapy for autosomal dominant disease in a murine model of dominant retinitis pigmentosa ER stress in retinal degeneration in S334ter Rho rats.The biochemistry, ultrastructure, and subunit assembly mechanism of AMPA receptors.Induction of the unfolded protein response by constitutive G-protein signaling in rod photoreceptor cells.Rhodopsin gene expression determines rod outer segment size and rod cell resistance to a dominant-negative neurodegeneration mutant Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration.Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.Inhibitory peptide of mitochondrial μ-calpain protects against photoreceptor degeneration in rhodopsin transgenic S334ter and P23H rats.Retinitis pigmentosa: genes and disease mechanisms.AAV delivery of wild-type rhodopsin preserves retinal function in a mouse model of autosomal dominant retinitis pigmentosa.Ablation of the proapoptotic genes CHOP or Ask1 does not prevent or delay loss of visual function in a P23H transgenic mouse model of retinitis pigmentosa Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa.Performance of protein disorder prediction programs on amino acid substitutions.Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems.Pharmacological chaperones for misfolded gonadotropin-releasing hormone receptors Intermittent but not constant high glucose induces ER stress and inflammation in human retinal pericytes Genotypic and phenotypic characterization of P23H line 1 rat model.An activated unfolded protein response promotes retinal degeneration and triggers an inflammatory response in the mouse retina.Small-molecule proteostasis regulators for protein conformational diseases.IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin Glucose-regulated protein 78 may play a crucial role in promoting the pulmonary microvascular remodeling in a rat model of hepatopulmonary syndrome

P2860

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P2860

Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78

http://www.wikidata.org/entity/Q33778232

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Restoration of visual function ...... by gene delivery of BiP/Grp78

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Restoration of visual function ...... by gene delivery of BiP/Grp78

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type

label

Restoration of visual function ...... by gene delivery of BiP/Grp78

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Restoration of visual function ...... by gene delivery of BiP/Grp78

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Restoration of visual function ...... by gene delivery of BiP/Grp78

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Restoration of visual function ...... by gene delivery of BiP/Grp78

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PNAS.0911991107

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Proceedings of the National Academy of Sciences of the United States of America

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Restoration of visual function ...... by gene delivery of BiP/Grp78

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Jonathan H Lin

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Marina S Gorbatyuk

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Matthew M LaVail

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Nicholas Muzyczka

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Oleg S Gorbatyuk

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Syed M Noorwez

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Tessa Knox

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P2860

Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy

Stress protein GRP78 prevents apoptosis induced by calcium ionophore, ionomycin, but not by glycosylation inhibitor, tunicamycin, in human prostate cancer cells

Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78

Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation

Mutation spectrum of the rhodopsin gene among patients with autosomal dominant retinitis pigmentosa

Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa

A molecular chaperone inducer protects neurons from ER stress

Overexpression of endoplasmic reticulum-resident chaperone attenuates cardiomyocyte death induced by proteasome inhibition

Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death

ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

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5961-5966

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13

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Alfred S. Lewin

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2010-03-15T00:00:00Z

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41969119

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20231467

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