Dual roles for Pax-6: a transcriptional repressor of lens fiber cell-specific beta-crystallin genes.
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The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoterPalm is expressed in both developing and adult mouse lens and retina.Perturbing the ubiquitin pathway reveals how mitosis is hijacked to denucleate and regulate cell proliferation and differentiation in vivoA set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activitiesSuperactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteinsPaired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic developmentRegulation of c-maf gene expression by Pax6 in cultured cellsPhosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development.Identification of differentially expressed genes in mouse Pax6 heterozygous lenses.The molecular basis of defective lens development in the Iberian mole.Identification and expression of Hop, an atypical homeobox gene expressed late in lens fiber cell terminal differentiationIdentification of pax6-dependent gene regulatory networks in the mouse lens.Suppression of PAX6 promotes cell proliferation and inhibits apoptosis in human retinoblastoma cellsEyg and Ey Pax proteins act by distinct transcriptional mechanisms in Drosophila development.Pax6 expression is sufficient to induce a neurogenic fate in glial progenitors of the neonatal subventricular zoneDigital expression profiling of the compartmentalized translatome of Purkinje neuronsLoss of Sip1 leads to migration defects and retention of ectodermal markers during lens development.The Zeb proteins δEF1 and Sip1 may have distinct functions in lens cells following cataract surgery.3T3 cell lines stably expressing Pax6 or Pax6(5a)--a new tool used for identification of common and isoform specific target genesAssociation of high myopia with crystallin beta A4 (CRYBA4) gene polymorphisms in the linkage-identified MYP6 locus.Pax6 regulates gene expression in the vertebrate lens through miR-204Pax6; a pleiotropic player in development.PAX6 and congenital eye malformations.PHA-4/FoxA cooperates with TAM-1/TRIM to regulate cell fate restriction in the C. elegans foregutConditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotype.Regulation of gene expression by Pax6 in ocular cells: a case of tissue-preferred expression of crystallins in lens.JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure.Activation of the hedgehog signaling pathway in the developing lens stimulates ectopic FoxE3 expression and disruption in fiber cell differentiation.Tissue-specific regulation of the mouse alphaA-crystallin gene in lens via recruitment of Pax6 and c-Maf to its promoter.Functional properties of natural human PAX6 and PAX6(5a) mutantsGenetic and epigenetic mechanisms of gene regulation during lens development.Dual roles for Prox1 in the regulation of the chicken betaB1-crystallin promoter.Transcriptional activities of the Pax6 gene eyeless regulate tissue specificity of ectopic eye formation in Drosophila.Effects of elevated Pax6 expression and genetic background on mouse eye development.Temporal regulation of Ath5 gene expression during eye developmentPAX6 maintains β cell identity by repressing genes of alternative islet cell types.A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell.Structure and expression of the scallop Omega-crystallin gene. Evidence for convergent evolution of promoter sequences.Crystallization and preliminary X-ray analysis of the Pax6 paired domain bound to the Pax6 gene enhancer.
P2860
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P2860
Dual roles for Pax-6: a transcriptional repressor of lens fiber cell-specific beta-crystallin genes.
description
1998 nî lūn-bûn
@nan
1998 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Dual roles for Pax-6: a transc ...... pecific beta-crystallin genes.
@ast
Dual roles for Pax-6: a transc ...... pecific beta-crystallin genes.
@en
type
label
Dual roles for Pax-6: a transc ...... pecific beta-crystallin genes.
@ast
Dual roles for Pax-6: a transc ...... pecific beta-crystallin genes.
@en
prefLabel
Dual roles for Pax-6: a transc ...... pecific beta-crystallin genes.
@ast
Dual roles for Pax-6: a transc ...... pecific beta-crystallin genes.
@en
P2093
P2860
P356
P1476
Dual roles for Pax-6: a transc ...... specific beta-crystallin genes
@en
P2093
J I Haynes
J Piatigorsky
P2860
P304
P356
10.1128/MCB.18.9.5579
P407
P577
1998-09-01T00:00:00Z