Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets. - Wikidata - awgldk - TriplyDB

Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets.

Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets.

http://www.wikidata.org/entity/Q33780945

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Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration From integrative genomics to therapeutic targets Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation Rab GTPases, membrane trafficking and diseases Prognostic value of FGFR gene amplification in patients with different types of cancer: a systematic review and meta-analysis.Mammary gland stem cells and their application in breast cancer Phase I/IIa study evaluating the safety, efficacy, pharmacokinetics, and pharmacodynamics of lucitanib in advanced solid tumors FGF receptors: cancer biology and therapeutics Genomic alterations in breast cancer patients in betel quid and non betel quid chewers FGFR2 point mutations in 466 endometrioid endometrial tumors: relationship with MSI, KRAS, PIK3CA, CTNNB1 mutations and clinicopathological features An Integrative Genomics Approach for Associating GWAS Information with Triple-Negative Breast Cancer.An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer.Targeting oncogenic vulnerabilities in triple negative breast cancer: biological bases and ongoing clinical studies.Prognostic impact of fibroblast growth factor receptor 2 gene amplification in patients receiving fluoropyrimidine and platinum chemotherapy for metastatic and locally advanced unresectable gastric cancers.In silico analysis identifies genes common between five primary gastrointestinal cancer sites with potential clinical applications.Identification and use of biomarkers in treatment strategies for triple-negative breast cancer subtypes.Novel therapeutic strategies in the treatment of triple-negative breast cancer.Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in breast cancer.Triple-negative breast cancer: the importance of molecular and histologic subtyping, and recognition of low-grade variants.Mammary gland growth factors: roles in normal development and in cancer.The Met oncogene and basal-like breast cancer: another culprit to watch out for?Treatment options for patients with triple-negative breast cancer A study on genetic variants of Fibroblast growth factor receptor 2 (FGFR2) and the risk of breast cancer from North India An integrated approach to uncover drivers of cancer.Combined analysis of genome-wide expression and copy number profiles to identify key altered genomic regions in cancer.The Fibroblast Growth Factor signaling pathway Molecular characterisation of cell line models for triple-negative breast cancers.Differential roles of fibroblast growth factor receptors (FGFR) 1, 2 and 3 in the regulation of S115 breast cancer cell growth FGFR2 promotes breast tumorigenicity through maintenance of breast tumor-initiating cells.Fibroblast growth factor receptors in breast cancer.Minireview: Basal-like breast cancer: from molecular profiles to targeted therapies MicroRNAs 206 and 21 cooperate to promote RAS-extracellular signal-regulated kinase signaling by suppressing the translation of RASA1 and SPRED1 Pharmacological profiling of kinase dependency in cell lines across triple-negative breast cancer subtypes.Genomic insights into triple-negative and HER2-positive breast cancers using isogenic model systems The landscape of candidate driver genes differs between male and female breast cancer.Functional analysis of a breast cancer-associated FGFR2 single nucleotide polymorphism using zinc finger mediated genome editing.New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing.Rationale for targeting fibroblast growth factor receptor signaling in breast cancer

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P2860

Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets.

http://www.wikidata.org/entity/Q33780945

description

2010 nî lūn-bûn

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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2010年の論文

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Integrative molecular profilin ...... potential therapeutic targets.

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P2860

Genome-wide association study identifies novel breast cancer susceptibility loci

Characterization of fibroblast growth factor receptor 2 overexpression in the human breast cancer cell line SUM-52PE

Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation.

DNA copy number alterations and expression of relevant genes in triple-negative breast cancer

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Patterns of somatic mutation in human cancer genomes

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

Hallmarks of 'BRCAness' in sporadic cancers

Genomic and transcriptional aberrations linked to breast cancer pathophysiologies

The molecular portraits of breast tumors are conserved across microarray platforms.

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2013-2023

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10.1038/ONC.2009.489

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14

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29

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Rachael Natrajan

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41139541

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1052564005

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20101236

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