p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.
about
Distinct biological activities of C3 and ADP-ribosyltransferase-deficient C3-E174QStress- and Rho-activated ZO-1-associated nucleic acid binding protein binding to p21 mRNA mediates stabilization, translation, and cell survivalThe gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoterIdentification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-IMyocardin related transcription factors are required for coordinated cell cycle progression.Activation of the p21WAF1/CIP1 promoter independent of p53 by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through the Sp1 sites.Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds.Mixed-lineage kinase 3 deficiency promotes neointima formation through increased activation of the RhoA pathway in vascular smooth muscle cellsSp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer.RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism involving activator protein 1.Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies.Blocking oncogenic Ras signaling for cancer therapy.A role for both Ets and C/EBP transcription factors and mRNA stabilization in the MAPK-dependent increase in p21 (Cip-1/WAF1/mda6) protein levels in primary hepatocytes.Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.Identification of herpesvirus proteins that contribute to G1/S arrest.Therapeutic efficacy of prenylation inhibitors in the treatment of myeloid leukemia.3-Hydroxy-3-methylglutaryl CoA reductase inhibitors up-regulate transforming growth factor-beta signaling in cultured heart cells via inhibition of geranylgeranylation of RhoA GTPase.Rho GTPases as key transducers of proliferative signals in g1 cell cycle regulation.GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer.Nanoformulation of Geranylgeranyltransferase-I Inhibitors for Cancer Therapy: Liposomal Encapsulation and pH-Dependent Delivery to Cancer Cells.Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells.Dual stimulation of Ras/mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression.Expression and significance of RhoC gene in hepatocellular carcinoma.Electrical and mechanical stimulation of cardiac cells and tissue constructs.Rho GTPases and cell cycle control.Roles for basal and stimulated p21(Cip-1/WAF1/MDA6) expression and mitogen-activated protein kinase signaling in radiation-induced cell cycle checkpoint control in carcinoma cells.Combination regimen with statins and NSAIDs: a promising strategy for cancer chemoprevention.DNA methylation-mediated nucleosome dynamics and oncogenic Ras signaling: insights from FAS, FAS ligand and RASSF1A.Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.Post-transcriptional destabilization of p21cip1 by protein kinase C in fibroblasts.Palmitoylated cysteine 192 is required for RhoB tumor-suppressive and apoptotic activities.Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradationC3 exoenzyme impairs cell proliferation and apoptosis by altering the activity of transcription factors.Retinoic acid amide inhibits JAK/STAT pathway in lung cancer which leads to apoptosis.Involvement of RhoA and RalB in geranylgeranyltransferase I inhibitor-mediated inhibition of proliferation and migration of human oral squamous cell carcinoma cells.Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21.Effects of rho kinase and actin stress fibers on sustained extracellular signal-regulated kinase activity and activation of G(1) phase cyclin-dependent kinases.Synergistic actions of atorvastatin with gamma-tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells.Increased expression of integrin beta1 subunit enhances p21WAF1/Cip1 transcription through the Sp1 sites and p300-mediated histone acetylation in human hepatocellular carcinoma cells.The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms.
P2860
Q24329196-AE71C8C3-AAFF-49CF-B1A8-CCE6E57AD176Q24338583-4B6B5CC9-A0D9-4BAC-A6EB-EC77050B30D9Q24653488-8DDA8EB9-E989-4FCE-BE55-CEFB50C9CE8CQ28477527-360C1AF5-23CC-4E89-A60A-5B3DC16BFCD8Q30317820-F3040AED-4065-43EF-91DF-22E7B25B62B6Q31750307-9BD9DAC8-996C-4BD9-B539-FA821BF5051DQ33317126-0D1CF421-4EF6-4B71-B33E-DD9D864A33B0Q33855025-3F876C7C-D4B7-47CF-90B7-3BA69DE6A060Q33952921-6E07E898-621B-4155-BD0F-5F60AE62721EQ34104943-17557246-6CB4-4260-8A25-521430D65D52Q34293555-F00D15A9-EF6D-4844-9F77-5760143F8BE9Q34311585-B4127C00-5BA2-404A-86FE-60FC7D53D8E9Q34749652-A487265C-9B2F-4E88-87CA-7212D402D9A6Q34940620-CF37F1F2-A281-4923-AD6C-6EAF3D1F4BDDQ35087201-48E1DFBB-445C-4FED-B773-44B277EBF44AQ35186888-4A88040E-87A6-4CA8-91A2-AC8A229B1321Q35654989-BC64F979-07FD-4E0B-91AA-EC2A674E1AB4Q35681628-929A290D-E33C-4CD6-87E3-CF2DF64635A5Q35762090-2F524BE2-F068-4B15-9B72-134571A208E5Q35767648-CCCA227C-7241-463E-9EB6-8DB221FDFCEFQ36259633-25B8E964-36AA-4126-95FD-45FF17450BC1Q36293708-E34A5053-DCF4-486F-860B-3CFFDE5DC8ADQ36309178-432C7DE1-869C-4FE8-9580-00B1111DA5B7Q36421781-7EC48F5E-AB99-4483-B591-384D33356170Q36693460-A92BA291-9A19-4586-8929-FFA2D24BE4EDQ36954987-7E57639D-2F3F-41D1-A5D2-35460DC37C3FQ37189495-D68F72EE-575E-4D89-BDF8-6B9C7027F231Q37273862-1E9BF5A8-6B81-490E-976B-BB4829FFE7AFQ37734257-564D40B7-3FDC-4819-92DE-959B8E626BB0Q38308539-0650CA2E-EBFA-4AAE-A077-74E71BB7F3E4Q38330587-61A3AADA-A3FC-4377-B954-BD04E512810BQ38355051-501DE09D-7B8B-4174-827E-D7811B686CB1Q38761317-59DDB2F4-1FA4-48B9-8AC2-4CD7355E1F48Q38867420-798EAC24-F24F-4F03-8991-99754422F85EQ39627631-82587C6E-D917-41AD-837F-4FAA7313EE77Q39653631-DA388A41-BA61-4766-AAE0-FD813F029151Q39756694-FB3D679C-32B1-44B9-BF45-5CDBA41E31BDQ39821838-F8EDF496-2AE6-4E54-82C4-0EAFD4AB66F4Q40185173-297B3FF5-6F9E-43C6-92D1-C1D79E54D2A6Q40273270-35753184-D77F-414D-87A1-95B9564E983D
P2860
p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
p21(WAF1/CIP1) is upregulated ...... ment of the small GTPase rhoA.
@ast
p21(WAF1/CIP1) is upregulated ...... ment of the small GTPase rhoA.
@en
type
label
p21(WAF1/CIP1) is upregulated ...... ment of the small GTPase rhoA.
@ast
p21(WAF1/CIP1) is upregulated ...... ment of the small GTPase rhoA.
@en
prefLabel
p21(WAF1/CIP1) is upregulated ...... ment of the small GTPase rhoA.
@ast
p21(WAF1/CIP1) is upregulated ...... ment of the small GTPase rhoA.
@en
P2093
P2860
P356
P1476
p21(WAF1/CIP1) is upregulated ...... ment of the small GTPase rhoA.
@en
P2093
P2860
P304
P356
10.1128/MCB.18.12.6962
P407
P577
1998-12-01T00:00:00Z