A gating mechanism proposed from a simulation of a human alpha7 nicotinic acetylcholine receptor
about
End-plate acetylcholine receptor: structure, mechanism, pharmacology, and diseaseMammalian nicotinic acetylcholine receptors: from structure to functionSize matters in activation/inhibition of ligand-gated ion channelsPathways and Barriers for Ion Translocation through the 5-HT3A Receptor ChannelDecrypting the sequence of structural events during the gating transition of pentameric ligand-gated ion channels based on an interpolated elastic network modelCrystal Structures of a Cysteine-modified Mutant in Loop D of Acetylcholine-binding ProteinRecent advances in Cys-loop receptor structure and functionA Structural Model of the Human α7 Nicotinic Receptor in an Open ConformationEmbedded cholesterol in the nicotinic acetylcholine receptorModeling and simulation of ion channels.cAMP Modulation of the cytoplasmic domain in the HCN2 channel investigated by molecular simulations.In silico models for the human alpha4beta2 nicotinic acetylcholine receptor.Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors.Mechanics of channel gating of the nicotinic acetylcholine receptor.Higher susceptibility to halothane modulation in open- than in closed-channel alpha4beta2 nAChR revealed by molecular dynamics simulationsIon conduction in ligand-gated ion channels: Brownian dynamics studies of four recent crystal structures.Analysis of the gastric H,K ATPase for ion pathways and inhibitor binding sites.Mapping spatial relationships between residues in the ligand-binding domain of the 5-HT3 receptor using a molecular rulerUnresponsive correlated motion in alpha7 nAChR to halothane binding explains its functional insensitivity to volatile anesthetics.Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain.Molecular tuning of fast gating in pentameric ligand-gated ion channels.An energy-efficient gating mechanism in the acetylcholine receptor channel suggested by molecular and Brownian dynamics.Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor.Structural answers and persistent questions about how nicotinic receptors work.Therapeutics of 5-HT3 receptor antagonists: current uses and future directions.Partitioning of anesthetics into a lipid bilayer and their interaction with membrane-bound peptide bundlesConformational changes in acetylcholine binding protein investigated by temperature accelerated molecular dynamics.Isoflurane alters the structure and dynamics of GLIC.Nanosecond-timescale conformational dynamics of the human alpha7 nicotinic acetylcholine receptor.Dynamic structural investigations on the torpedo nicotinic acetylcholine receptor by time-resolved photoaffinity labeling.GABA binding to an insect GABA receptor: a molecular dynamics and mutagenesis study.Spontaneous conformational change and toxin binding in alpha7 acetylcholine receptor: insight into channel activation and inhibitionInteraction of anesthetics with open and closed conformations of a potassium channel studied via molecular dynamics and normal mode analysisNicotinic receptor interloop proline anchors beta1-beta2 and Cys loops in coupling agonist binding to channel gating.Potentials of mean force for acetylcholine unbinding from the alpha7 nicotinic acetylcholine receptor ligand-binding domain.Gating of nicotinic ACh receptors; new insights into structural transitions triggered by agonist binding that induce channel opening.Pore-opening mechanism of the nicotinic acetylcholine receptor evinced by proton transfer.Ligand-specific conformational changes in the alpha1 glycine receptor ligand-binding domainStructural rearrangements in loop F of the GABA receptor signal ligand binding, not channel activation.Molecular-dynamics simulations of ELIC-a prokaryotic homologue of the nicotinic acetylcholine receptor.
P2860
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P2860
A gating mechanism proposed from a simulation of a human alpha7 nicotinic acetylcholine receptor
description
2005 nî lūn-bûn
@nan
2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
A gating mechanism proposed fr ...... cotinic acetylcholine receptor
@ast
A gating mechanism proposed fr ...... cotinic acetylcholine receptor
@en
type
label
A gating mechanism proposed fr ...... cotinic acetylcholine receptor
@ast
A gating mechanism proposed fr ...... cotinic acetylcholine receptor
@en
prefLabel
A gating mechanism proposed fr ...... cotinic acetylcholine receptor
@ast
A gating mechanism proposed fr ...... cotinic acetylcholine receptor
@en
P2860
P356
P1476
A gating mechanism proposed fr ...... cotinic acetylcholine receptor
@en
P2093
Richard H Henchman
Richard J Law
P2860
P304
P356
10.1073/PNAS.0407739102
P407
P577
2005-04-27T00:00:00Z