Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors

Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors

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http://www.wikidata.org/entity/Q33784436
The utility of transposon mutagenesis for cancer studies in the era of genome editing.RAF inhibitors that evade paradoxical MAPK pathway activationDetailed imaging and genetic analysis reveal a secondary BRAF(L505H) resistance mutation and extensive intrapatient heterogeneity in metastatic BRAF mutant melanoma patients treated with vemurafenib.Exploring Molecular Mechanisms of Paradoxical Activation in the BRAF Kinase Dimers: Atomistic Simulations of Conformational Dynamics and Modeling of Allosteric Communication Networks and Signaling Pathways.Inhibition of mutant BRAF splice variant signaling by next-generation, selective RAF inhibitors.Targeting RAS-mutant cancers: is ERK the key?Vitamin C at high concentrations induces cytotoxicity in malignant melanoma but promotes tumor growth at low concentrations.Targeting protein kinase-b3 (akt3) signaling in melanoma.Inhibition of the CRAF/prohibitin interaction reverses CRAF-dependent resistance to vemurafenib.Genomic landscape of cutaneous T cell lymphoma.PLX8394, a new generation BRAF inhibitor, selectively inhibits BRAF in colonic adenocarcinoma cells and prevents paradoxical MAPK pathway activation.Are there multiple cells of origin of Merkel cell carcinoma?KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer.Design of potent B-RafV600E inhibitors by multiple copy simulation search strategy.Response and Resistance to Paradox-Breaking BRAF Inhibitor in Melanomas In Vivo and Ex Vivo.Transposon Insertion Site Sequencing (TIS-Seq): An Efficient and High-Throughput Method for Determining Transposon Insertion Site(s) and Their Relative Abundances in a PiggyBac Transposon Mutant Pool by Next-Generation Sequencing.YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics.
P2860

Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors

Item
http://www.wikidata.org/entity/Q33784436
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2014 nî lūn-bûn
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2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors
@ast
Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors
@en
type
label
Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors
@ast
Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors
@en
prefLabel
Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors
@ast
Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P932
P356
P1433
P1476
Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P932