Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma - Wikidata - awgldk - TriplyDB

Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma

Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma

http://www.wikidata.org/entity/Q33794045

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Cell Proliferation in Neuroblastoma Preclinical evaluation of engineered oncolytic herpes simplex virus for the treatment of neuroblastoma Preclinical evaluation of engineered oncolytic herpes simplex virus for the treatment of pediatric solid tumors Evolving Therapies and FAK Inhibitors for the Treatment of Cancer Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1.A simple knowledge-based mining method for exploring hidden key molecules in a human biomolecular network.PKCθ signaling is required for myoblast fusion by regulating the expression of caveolin-3 and β1D integrin upstream focal adhesion kinase.Inhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma.MYCN, neuroblastoma and focal adhesion kinase (FAK)Targeting focal adhesion kinase in neuroblastoma.Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated.Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death.Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide.FAK Inhibition Decreases Hepatoblastoma Survival Both In Vitro and In Vivo.FAK inhibition decreases cell invasion, migration and metastasis in MYCN amplified neuroblastoma FAK is a critical regulator of neuroblastoma liver metastasis.Cell survival signaling in neuroblastoma.Targeting Focal Adhesion Kinase Suppresses the Malignant Phenotype in Rhabdomyosarcoma Cells Efficacy of focal adhesion kinase inhibition in non-small cell lung cancer with oncogenically activated MAPK pathways.Inhibition of the focal adhesion kinase and vascular endothelial growth factor receptor-3 interaction leads to decreased survival in human neuroblastoma cell lines.Targeting the p53 pathway.Focal adhesion kinase autophosphorylation inhibition decreases colon cancer cell growth and enhances the efficacy of chemotherapy.Effect of Repeat Dosing of Engineered Oncolytic Herpes Simplex Virus on Preclinical Models of Rhabdomyosarcoma MiR-138 and MiR-135 directly target focal adhesion kinase, inhibit cell invasion, and increase sensitivity to chemotherapy in cancer cells.FAK inhibition abrogates the malignant phenotype in aggressive pediatric renal tumors Focal adhesion kinase as a cancer therapy target.FAK and Nanog cross talk with p53 in cancer stem cells.Targeting FAK in human cancer: from finding to first clinical trials.N-Myc expression enhances the oncolytic effects of vesicular stomatitis virus in human neuroblastoma cells Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15.Activated αvβ3 integrin regulates αvβ5 integrin-mediated phagocytosis in trabecular meshwork cells.In vivo toxicity, metabolism and pharmacokinetic properties of FAK inhibitor 14 or Y15 (1, 2, 4, 5-benzenetetramine tetrahydrochloride).In vitro activities of hexaazatrinaphthylenes against Leishmania spp The microarray gene profiling analysis of glioblastoma cancer cells reveals genes affected by FAK inhibitor Y15 and combination of Y15 and temozolomide.Focal adhesion kinase regulates neuronal growth, synaptic plasticity and hippocampus-dependent spatial learning and memory.Fine-tuning Tumor Immunity with Integrin Trans-regulation.Inhibition of cell migration by focal adhesion kinase: Time-dependent difference in integrin-induced signaling between endothelial and hepatoblastoma cells.

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P2860

Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma

http://www.wikidata.org/entity/Q33794045

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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name

Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma

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Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma

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type

label

Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma

@ast

Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma

@en

prefLabel

Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma

@ast

Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma

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P1476

Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma

@en

P2093

Angelica Trujillo

http://www.w3.org/2001/XMLSchema#string

Carl Nyberg

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Elizabeth A Beierle

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Jerry Stewart

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Vita M Golubovskaya

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William G Cance

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Xiaojie Ma

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P2860

Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271

FAK integrates growth-factor and integrin signals to promote cell migration

FAK regulates biological processes important for the pathogenesis of cancer

Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage

Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors

Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.

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1005-1015

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20160475

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