SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53

SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53

Item

http://www.wikidata.org/entity/Q33795918

Q33795918

about

Chemical Variations on the p53 Reactivation Theme Targeting Oncogenic Mutant p53 for Cancer Therapy Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising The p53 pathway as a target in cancer therapeutics: obstacles and promise Genetic stability of bone marrow-derived human mesenchymal stromal cells in the Quantum System Wild type p53 reactivation: from lab bench to clinic.CHOPER filters enable rare mutation detection in complex mutagenesis populations by next-generation sequencing.Translational approaches targeting the p53 pathway for anti-cancer therapy.Towards an understanding of the role of p53 in adrenocortical carcinogenesis.Targeting the p53 signaling pathway in cancer therapy - the promises, challenges and perils.Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53.Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells.Pharmacological activation of p53 in cancer cells Targeting the p53 pathway.Quinazoline derivatives as potential anticancer agents: a patent review (2007 - 2010).Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme.Mutant p53 in cancer: new functions and therapeutic opportunities.Pharmacological reactivation of p53 as a strategy to treat cancer.Cellular signaling pathways implicated in metastasis of colorectal cancer and the associated targeted agents.Synthesis and cytotoxicity studies of novel benzhydrylpiperazine carboxamide and thioamide derivatives.Reviving the guardian of the genome: Small molecule activators of p53.Small molecules as activators in medicinal chemistry (2000-2016).The genomics of lung adenocarcinoma: opportunities for targeted therapies.Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others.An in silico approach in predicting the possible mechanism involving restoration of wild-type p53 functions by small molecular weight compounds in tumor cells expressing R273H mutant p53.A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells.

P2860

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P2860

SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53

Item

http://www.wikidata.org/entity/Q33795918

description

2010 nî lūn-bûn

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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

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2010年论文

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