A global neutralization resistance phenotype of human immunodeficiency virus type 1 is determined by distinct mechanisms mediating enhanced infectivity and conformational change of the envelope complex.
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Induction of a Tier-1-like Phenotype in Diverse Tier-2 Isolates by Agents that Guide HIV-1 Env to Perturbation-sensitive, Non-native States.Identification and characterization of a new cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody.Enhancing exposure of HIV-1 neutralization epitopes through mutations in gp41.Genetic signatures in the envelope glycoproteins of HIV-1 that associate with broadly neutralizing antibodies.Immunoreactivity of intact virions of human immunodeficiency virus type 1 (HIV-1) reveals the existence of fewer HIV-1 immunotypes than genotypes.Envelope glycoprotein determinants of neutralization resistance in a simian-human immunodeficiency virus (SHIV-HXBc2P 3.2) derived by passage in monkeys.During readaptation in vivo, a tissue culture-adapted strain of feline immunodeficiency virus reverts to broad neutralization resistance at different times in individual hosts but through changes at the same position of the surface glycoprotein.Genetic subtypes, humoral immunity, and human immunodeficiency virus type 1 vaccine development.Feline immunodeficiency virus-infected cat sera associated with the development of broad neutralization resistance in vivo drive similar reversions in vitro.Contribution of intrinsic reactivity of the HIV-1 envelope glycoproteins to CD4-independent infection and global inhibitor sensitivity.Human monoclonal antibodies specific for conformation-sensitive epitopes of V3 neutralize human immunodeficiency virus type 1 primary isolates from various clades.A variable region 3 (V3) mutation determines a global neutralization phenotype and CD4-independent infectivity of a human immunodeficiency virus type 1 envelope associated with a broadly cross-reactive, primary virus-neutralizing antibody responseConcordant modulation of neutralization resistance and high infectivity of the primary human immunodeficiency virus type 1 MN strain and definition of a potential gp41 binding site in gp120.Induction of neutralizing antibodies to Hendra and Nipah glycoproteins using a Venezuelan equine encephalitis virus in vivo expression system.Neutralizing antibody responses in macaques induced by human immunodeficiency virus type 1 monovalent or trivalent envelope glycoproteins.MPER-specific antibodies induce gp120 shedding and irreversibly neutralize HIV-1.Induction of primary virus-cross-reactive human immunodeficiency virus type 1-neutralizing antibodies in small animals by using an alphavirus-derived in vivo expression systemUnique V3 loop sequence derived from the R2 strain of HIV-type 1 elicits broad neutralizing antibodies.Multiple interactions across the surface of the gp120 core structure determine the global neutralization resistance phenotype of human immunodeficiency virus type 1The role of amino acid changes in the human immunodeficiency virus type 1 transmembrane domain in antibody binding and neutralizationNeutralizing antibody escape during HIV-1 mother-to-child transmission involves conformational masking of distal epitopes in envelope.Mutations in envelope gp120 can impact proteolytic processing of the gp160 precursor and thereby affect neutralization sensitivity of human immunodeficiency virus type 1 pseudoviruses.N-terminal substitutions in HIV-1 gp41 reduce the expression of non-trimeric envelope glycoproteins on the virus.The v3 loop is accessible on the surface of most human immunodeficiency virus type 1 primary isolates and serves as a neutralization epitope.Evolution of two amino acid positions governing broad neutralization resistance in a strain of feline immunodeficiency virus over 7 years of persistence in cats.Nonneutralizing antibodies to the CD4-binding site on the gp120 subunit of human immunodeficiency virus type 1 do not interfere with the activity of a neutralizing antibody against the same siteIdentification of novel structural determinants in MW965 Env that regulate the neutralization phenotype and conformational masking potential of primary HIV-1 isolates.
P2860
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P2860
A global neutralization resistance phenotype of human immunodeficiency virus type 1 is determined by distinct mechanisms mediating enhanced infectivity and conformational change of the envelope complex.
description
2000 nî lūn-bûn
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2000年の論文
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name
A global neutralization resist ...... hange of the envelope complex.
@ast
A global neutralization resist ...... hange of the envelope complex.
@en
type
label
A global neutralization resist ...... hange of the envelope complex.
@ast
A global neutralization resist ...... hange of the envelope complex.
@en
prefLabel
A global neutralization resist ...... hange of the envelope complex.
@ast
A global neutralization resist ...... hange of the envelope complex.
@en
P2093
P2860
P1433
P1476
A global neutralization resist ...... hange of the envelope complex.
@en
P2093
G V Quinnan
S Zolla-Pazner
P2860
P304
P356
10.1128/JVI.74.9.4183-4191.2000
P577
2000-05-01T00:00:00Z