Synthetic associations are unlikely to account for many common disease genome-wide association signals
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Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritabilityJumping on the Train of Personalized Medicine: A Primer for Non-Geneticist Clinicians: Part 2. Fundamental Concepts in Genetic EpidemiologyPersonalized medicine: hope or hype?Five years of GWAS discoveryCopy number variants in obesity-related syndromes: review and perspectives on novel molecular approachesClinical review: Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headedThe power of meta-analysis in genome-wide association studiesThe genetic architecture of type 2 diabetesMutations Causing Complex Disease May under Certain Circumstances Be Protective in an Epidemiological Sense.A genome-wide association study of autism incorporating autism diagnostic interview-revised, autism diagnostic observation schedule, and social responsiveness scale.Common disease: are causative alleles common or rare?Comparative linkage meta-analysis reveals regionally-distinct, disparate genetic architectures: application to bipolar disorder and schizophrenia.Genetic architectures of psychiatric disorders: the emerging picture and its implications.Estimating causal effects of genetic risk variants for breast cancer using marker data from bilateral and familial cases.Recent methods for polygenic analysis of genome-wide data implicate an important effect of common variants on cardiovascular disease risk.Shared and independent colorectal cancer risk alleles in TGFβ-related genes in African and European AmericansA case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population.Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients.Predicting signatures of "synthetic associations" and "natural associations" from empirical patterns of human genetic variation.Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patternsUnbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C.Capture Hi-C identifies the chromatin interactome of colorectal cancer risk lociCase-control association testing of common variants from sequencing of DNA pools.High trans-ethnic replicability of GWAS results implies common causal variants.The effect of paternal age on offspring intelligence and personality when controlling for paternal trait levelRare and common variants: twenty arguments.Comprehensive resequence analysis of a 123-kb region of chromosome 11q13 associated with prostate cancerGWASeq: targeted re-sequencing follow up to GWAS.Role of cytokines in systemic lupus erythematosus: recent progress from GWAS and sequencing.Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function.Explaining additional genetic variation in complex traitsIdentifying plausible genetic models based on association and linkage results: application to type 2 diabetesChallenges and opportunities in genome-wide environmental interaction (GWEI) studiesAssociation analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.Common biological networks underlie genetic risk for alcoholism in African- and European-American populations.Mapping cis- and trans-regulatory effects across multiple tissues in twins.Extended haplotype association study in Crohn's disease identifies a novel, Ashkenazi Jewish-specific missense mutation in the NF-κB pathway gene, HEATR3Next-generation sequencing in understanding complex neurological diseaseA genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1.Synthetic associations in the context of genome-wide association scan signals.
P2860
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P2860
Synthetic associations are unlikely to account for many common disease genome-wide association signals
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Synthetic associations are unl ...... enome-wide association signals
@ast
Synthetic associations are unl ...... enome-wide association signals
@en
type
label
Synthetic associations are unl ...... enome-wide association signals
@ast
Synthetic associations are unl ...... enome-wide association signals
@en
prefLabel
Synthetic associations are unl ...... enome-wide association signals
@ast
Synthetic associations are unl ...... enome-wide association signals
@en
P2860
P50
P1433
P1476
Synthetic associations are unl ...... enome-wide association signals
@en
P2860
P304
P356
10.1371/JOURNAL.PBIO.1000580
P407
P577
2011-01-18T00:00:00Z