In vivo induction of a high-avidity, high-frequency cytotoxic T-lymphocyte response is associated with antiviral protective immunity
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αβ TCR-mediated recognition: relevance to tumor-antigen discovery and cancer immunotherapyDeveloping Combined HIV Vaccine Strategies for a Functional CureEmerging concepts in immunity to hepatitis C virus infection.Forward Vaccinology: CTL Targeting Based upon Physical Detection of HLA-Bound PeptidesIncreased Cytotoxic T-Lymphocyte Epitope Variant Cross-Recognition and Functional Avidity Are Associated with Hepatitis C Virus ClearanceEpitope-specific TCR repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptidesStructural and Functional Correlates of Enhanced Antiviral Immunity Generated by Heteroclitic CD8 T Cell EpitopesHigh avidity cytotoxic T lymphocytes can be selected into the memory pool but they are exquisitely sensitive to functional impairmentVaccine efficacy against malaria by the combination of porcine parvovirus-like particles and vaccinia virus vectors expressing CS of PlasmodiumCTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV controlDNA vaccines against human immunodeficiency virus type 1.Conservation and diversity of influenza A H1N1 HLA-restricted T cell epitope candidates for epitope-based vaccines.CD4+ T cell subset differentiation and avidity setpoint are dictated by the interplay of cytokine and antigen mediated signalsEffective simian immunodeficiency virus-specific CD8+ T cells lack an easily detectable, shared characteristic.Altered function in CD8+ T cells following paramyxovirus infection of the respiratory tract.Protective efficacy of serially up-ranked subdominant CD8+ T cell epitopes against virus challengesIn vivo delivery of antigens by adenovirus dodecahedron induces cellular and humoral immune responses to elicit antitumor immunity.Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover.Escape is a more common mechanism than avidity reduction for evasion of CD8+ T cell responses in primary human immunodeficiency virus type 1 infection.A highly optimized DNA vaccine confers complete protective immunity against high-dose lethal lymphocytic choriomeningitis virus challenge.Clonotype and repertoire changes drive the functional improvement of HIV-specific CD8 T cell populations under conditions of limited antigenic stimulation.Selective depletion of high-avidity human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells after early HIV-1 infectionVaccines that facilitate antigen entry into dendritic cells.Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infectionCD8alpha- CD11b+ dendritic cells present exogenous virus-like particles to CD8+ T cells and subsequently express CD8alpha and CD205 molecules.Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA virusesNuclear localization of avian polyomavirus structural protein VP1 is a prerequisite for the formation of virus-like particles.Cutting edge: Dendritic cells prime a high avidity CTL response independent of the level of presented antigen.Age-related appearance of a CMV-specific high-avidity CD8+ T cell clonotype which does not occur in young adults.In vivo modulation of avidity in highly sensitive CD8(+) effector T cells following viral infectionTricks with tetramers: how to get the most from multimeric peptide-MHC.T cell sensitivity and the outcome of viral infection.Vaccines as early therapeutic interventions for cancer therapy: neutralising the immunosuppressive tumour environment and increasing T cell avidity may lead to improved responses.Enhanced cytotoxicity and decreased CD8 dependence of human cancer-specific cytotoxic T lymphocytes after vaccination with low peptide dose.Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell ResponsesCD8αα Expression Marks Terminally Differentiated Human CD8+ T Cells Expanded in Chronic Viral Infection.The hypervariable immunodominant NP418-426 epitope from the influenza A virus nucleoprotein is recognized by cytotoxic T lymphocytes with high functional avidityInfluence of minor displacements in loops of the porcine parvovirus VP2 capsid on virus-like particles assembly and the induction of antibody responses.Increased sensitivity to antigen in high avidity CD8(+) T cells results from augmented membrane proximal T-cell receptor signal transduction.Changes to peptide structure, not concentration, contribute to expansion of the lowest avidity cytotoxic T lymphocytes.
P2860
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P2860
In vivo induction of a high-avidity, high-frequency cytotoxic T-lymphocyte response is associated with antiviral protective immunity
description
2000 nî lūn-bûn
@nan
2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
In vivo induction of a high-av ...... antiviral protective immunity
@ast
In vivo induction of a high-av ...... antiviral protective immunity
@en
type
label
In vivo induction of a high-av ...... antiviral protective immunity
@ast
In vivo induction of a high-av ...... antiviral protective immunity
@en
prefLabel
In vivo induction of a high-av ...... antiviral protective immunity
@ast
In vivo induction of a high-av ...... antiviral protective immunity
@en
P2093
P2860
P1433
P1476
In vivo induction of a high-av ...... antiviral protective immunity
@en
P2093
P2860
P304
P356
10.1128/JVI.74.13.5769-5775.2000
P577
2000-07-01T00:00:00Z