Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1.
about
Granule exocytosis is required for platelet spreading: differential sorting of α-granules expressing VAMP-7Diversity and modularity of G protein-coupled receptor structuresEndogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments.Membrane-sensitive conformational states of helix 8 in the metabotropic Glu2 receptor, a class C GPCRDiscovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor.Allosteric modulation of protease-activated receptor signaling.Platelet specific promoters are insufficient to express protease activated receptor 1 (PAR1) transgene in mouse platelets.Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar.Proteomic analysis of palmitoylated platelet proteinsAllosteric Activation of a G Protein-coupled Receptor with Cell-penetrating Receptor MimeticsAllosteric modulator ORG27569 induces CB1 cannabinoid receptor high affinity agonist binding state, receptor internalization, and Gi protein-independent ERK1/2 kinase activationVAMP-7 links granule exocytosis to actin reorganization during platelet activation.Natural products induce a G protein-mediated calcium pathway activating p53 in cancer cells.Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46.Distinct roles of β-arrestin 1 and β-arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor 1 (CB1).Palmitoylation of protease-activated receptor-1 regulates adaptor protein complex-2 and -3 interaction with tyrosine-based motifs and endocytic sorting.Protease-activated receptors in hemostasis.Targeting PAR1: Now What?A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer.Modulation of PAR(1) signalling by benzimidazole compounds.Helix 8 plays a crucial role in bradykinin B(2) receptor trafficking and signaling.PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury.Protease-Activated Receptor-1 Signaling: The Big Picture.Characterization of Protease-Activated Receptor (PAR) ligands: Parmodulins are reversible allosteric inhibitors of PAR1-driven calcium mobilization in endothelial cells.
P2860
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P2860
Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Identification of an antithrom ...... acts through helix 8 of PAR1.
@ast
Identification of an antithrom ...... acts through helix 8 of PAR1.
@en
type
label
Identification of an antithrom ...... acts through helix 8 of PAR1.
@ast
Identification of an antithrom ...... acts through helix 8 of PAR1.
@en
prefLabel
Identification of an antithrom ...... acts through helix 8 of PAR1.
@ast
Identification of an antithrom ...... acts through helix 8 of PAR1.
@en
P2093
P2860
P356
P1476
Identification of an antithrom ...... t acts through helix 8 of PAR1
@en
P2093
Athan Kuliopulos
Bradley M Denker
Derek S Sim
James R Dilks
Louisa Dowal
Price Blair
Robert Flaumenhaft
Sarah Beaudry
P2860
P304
P356
10.1073/PNAS.1014863108
P407
P577
2011-01-31T00:00:00Z