The human papillomavirus E6 oncogene dysregulates the cell cycle and contributes to cervical carcinogenesis through two independent activities. - Wikidata - awgldk - TriplyDB

The human papillomavirus E6 oncogene dysregulates the cell cycle and contributes to cervical carcinogenesis through two independent activities.

The human papillomavirus E6 oncogene dysregulates the cell cycle and contributes to cervical carcinogenesis through two independent activities.

http://www.wikidata.org/entity/Q33808527

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Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?The p53-estrogen receptor loop in cancer Structural Insights into a Wildtype Domain of the Oncoprotein E6 and Its Interaction with a PDZ Domain Gene expression profile of cervical and skin tissues from human papillomavirus type 16 E6 transgenic mice.Potential anti-HPV and related cancer agents from marine resources: an overview.A role for HPV16 E5 in cervical carcinogenesis.HUMAN PAPILLOMAVIRUS ASSOCIATION WITH HEAD AND NECK CANCERS: UNDERSTANDING VIRUS BIOLOGY AND USING IT IN THE DEVELOPMENT OF CANCER DIAGNOSTICS Role of Rb-dependent and Rb-independent functions of papillomavirus E7 oncogene in head and neck cancer.p53 Loss synergizes with estrogen and papillomaviral oncogenes to induce cervical and breast cancers.E6-associated protein is required for human papillomavirus type 16 E6 to cause cervical cancer in mice.Human papillomavirus 16 E5 modulates the expression of host microRNAs Estrogen and ERalpha: culprits in cervical cancer?A mouse model for human anal cancer IGF axis and other factors in HPV-related and HPV-unrelated carcinogenesis (review).Requirement for Dlgh-1 in planar cell polarity and skeletogenesis during vertebrate development.Cancer-causing human papillomavirus E6 proteins display major differences in the phospho-regulation of their PDZ interactions.Regulation of cellular miRNA expression by human papillomaviruses.Emerging theme: cellular PDZ proteins as common targets of pathogenic viruses.Combined oral contraceptive use increases HPV persistence but not new HPV detection in a cohort of women from Thailand Dominant role of HPV16 E7 in anal carcinogenesis.The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.Cervical cancers require the continuous expression of the human papillomavirus type 16 E7 oncoprotein even in the presence of the viral E6 oncoprotein The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression.Molecular mechanisms of human papillomavirus-induced carcinogenesis.Cell polarity proteins: common targets for tumorigenic human viruses.Cellular binding partners of the human papillomavirus E6 protein.Requirement for stromal estrogen receptor alpha in cervical neoplasia The transcriptional regulator gene E2 of the Human Papillomavirus (HPV) 16 influences the radiosensitivity of cervical keratinocytes.High-risk human papillomavirus E6 oncoproteins interact with 14-3-3ζ in a PDZ binding motif-dependent manner Differential gene expression between skin and cervix induced by the E7 oncoprotein in a transgenic mouse model Effects of cellular differentiation, chromosomal integration and 5-aza-2'-deoxycytidine treatment on human papillomavirus-16 DNA methylation in cultured cell lines.Cellular transformation by human papillomaviruses: lessons learned by comparing high- and low-risk viruses Requirement for estrogen receptor alpha in a mouse model for human papillomavirus-associated cervical cancer.miR-2861 acts as a tumor suppressor via targeting EGFR/AKT2/CCND1 pathway in cervical cancer induced by human papillomavirus virus 16 E6 Early age at first sexual intercourse and early pregnancy are risk factors for cervical cancer in developing countries.Human papillomaviruses, cervical cancer and cell polarity.Large-scale analysis of protein expression changes in human keratinocytes immortalized by human papilloma virus type 16 E6 and E7 oncogenes.Prevention and treatment of cervical cancer in mice using estrogen receptor antagonists.microRNAs are biomarkers of oncogenic human papillomavirus infections.Papillomavirus-associated cutaneous neoplasia in mammals.

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P2860

The human papillomavirus E6 oncogene dysregulates the cell cycle and contributes to cervical carcinogenesis through two independent activities.

http://www.wikidata.org/entity/Q33808527

description

2007 nî lūn-bûn

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2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2007 թվականի փետրվարին հրատարակված գիտական հոդված

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2007年の論文

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0008-5472.CAN-06-3344

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Cancer Research

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The human papillomavirus E6 on ...... gh two independent activities.

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P2093

Anny Shai

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Chamorro Somoza

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Paul F Lambert

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Tiffany Brake

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P2860

Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer

UBE3A/E6-AP mutations cause Angelman syndrome

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase

Analysis of the expression and localisation of a LAP protein, human scribble, in the normal and neoplastic epithelium of uterine cervix

Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein

The causal relation between human papillomavirus and cervical cancer.

Requirement of PDZ-containing proteins for cell cycle regulation and differentiation in the mouse lens epithelium

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

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10.1158/0008-5472.CAN-06-3344

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