Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1
about
Molecular recognition of CCR5 by an HIV-1 gp120 V3 loopHIV-1 cell to cell transfer across an Env-induced, actin-dependent synapseGelsolin activity controls efficient early HIV-1 infectionDC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in transRole for CCR5Delta32 protein in resistance to R5, R5X4, and X4 human immunodeficiency virus type 1 in primary CD4+ cellsPit2 assemblies at the cell surface are modulated by extracellular inorganic phosphate concentrationP2X1 Receptor Antagonists Inhibit HIV-1 Fusion by Blocking Virus-Coreceptor InteractionsHIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 useAccelerated immunodeficiency by anti-CCR5 treatment in HIV infectionEstimating the threshold surface density of Gp120-CCR5 complexes necessary for HIV-1 envelope-mediated cell-cell fusionAllosteric modulation of the HIV-1 gp120-gp41 association site by adjacent gp120 variable region 1 (V1) N-glycans linked to neutralization sensitivityStoichiometry of envelope glycoprotein trimers in the entry of human immunodeficiency virus type 1Mechanisms of nonrandom human immunodeficiency virus type 1 infection and double infection: preference in virus entry is important but is not the sole factorVirological synapse-mediated spread of human immunodeficiency virus type 1 between T cells is sensitive to entry inhibitionElectron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions.Role of cholesterol in human immunodeficiency virus type 1 envelope protein-mediated fusion with host cellsElectron tomography of the contact between T cells and SIV/HIV-1: implications for viral entry.Early steps of HIV-1 fusion define the sensitivity to inhibitory peptides that block 6-helix bundle formation.Rapid dissociation of HIV-1 from cultured cells severely limits infectivity assays, causes the inactivation ascribed to entry inhibitors, and masks the inherently high level of infectivity of virions.Kinetic factors control efficiencies of cell entry, efficacies of entry inhibitors, and mechanisms of adaptation of human immunodeficiency virusVariants of human immunodeficiency virus type 1 that efficiently use CCR5 lacking the tyrosine-sulfated amino terminus have adaptive mutations in gp120, including loss of a functional N-glycanStoichiometry of antibody neutralization of human immunodeficiency virus type 1.DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virusAntigenically distinct conformations of CXCR4.Mutations within the putative membrane-spanning domain of the simian immunodeficiency virus transmembrane glycoprotein define the minimal requirements for fusion, incorporation, and infectivity.Targeting spare CC chemokine receptor 5 (CCR5) as a principle to inhibit HIV-1 entry.CD4-independent use of Rhesus CCR5 by human immunodeficiency virus Type 2 implicates an electrostatic interaction between the CCR5 N terminus and the gp120 C4 domain.Frequent substitution polymorphisms in African green monkey CCR5 cluster at critical sites for infections by simian immunodeficiency virus SIVagm, implying ancient virus-host coevolutionAdaptive mutations in the V3 loop of gp120 enhance fusogenicity of human immunodeficiency virus type 1 and enable use of a CCR5 coreceptor that lacks the amino-terminal sulfated regionReceptors and entry cofactors for retroviruses include single and multiple transmembrane-spanning proteins as well as newly described glycophosphatidylinositol-anchored and secreted proteins.Time-resolved imaging of HIV-1 Env-mediated lipid and content mixing between a single virion and cell membrane.Oligomeric beta-structure of the membrane-bound HIV-1 fusion peptide formed from soluble monomers.Segregation of CD4 and CXCR4 into distinct lipid microdomains in T lymphocytes suggests a mechanism for membrane destabilization by human immunodeficiency virusRole for human immunodeficiency virus type 1 membrane cholesterol in viral internalization.Similar regulation of cell surface human T-cell leukemia virus type 1 (HTLV-1) surface binding proteins in cells highly and poorly transduced by HTLV-1-pseudotyped virionsSensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kineticsIdentification of gp120 binding sites on CXCR4 by using CD4-independent human immunodeficiency virus type 2 Env proteins.CCR5 antibodies HGS004 and HGS101 preferentially inhibit drug-bound CCR5 infection and restore drug sensitivity of Maraviroc-resistant HIV-1 in primary cells.Attachment and fusion inhibitors potently prevent dendritic cell-driven HIV infectionAdaptive mutations in a human immunodeficiency virus type 1 envelope protein with a truncated V3 loop restore function by improving interactions with CD4.
P2860
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P2860
Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1
description
2000 nî lūn-bûn
@nan
2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Cooperation of multiple CCR5 c ...... immunodeficiency virus type 1
@ast
Cooperation of multiple CCR5 c ...... immunodeficiency virus type 1
@en
type
label
Cooperation of multiple CCR5 c ...... immunodeficiency virus type 1
@ast
Cooperation of multiple CCR5 c ...... immunodeficiency virus type 1
@en
prefLabel
Cooperation of multiple CCR5 c ...... immunodeficiency virus type 1
@ast
Cooperation of multiple CCR5 c ...... immunodeficiency virus type 1
@en
P2093
P2860
P1433
P1476
Cooperation of multiple CCR5 c ...... immunodeficiency virus type 1
@en
P2093
P2860
P304
P356
10.1128/JVI.74.15.7005-7015.2000
P577
2000-08-01T00:00:00Z