Contribution of inherited mutations in the BRCA2-interacting protein PALB2 to familial breast cancer.
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Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repairMutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencingGenomic/Epigenomic Alterations in Ovarian Carcinoma: Translational Insight into Clinical PracticePALB2: research reaching to clinical outcomes for women with breast cancerInherited pancreatic cancer syndromesPalb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancerPioneering geneticist Mary-Claire King receives the 2014 Lasker~Koshland Special Achievement Award in Medical ScienceNovel germline PALB2 truncating mutations in African American breast cancer patientsInherited Mutations in Women With Ovarian CarcinomaRare germline mutations in PALB2 and breast cancer risk: a population-based study.Assessment of PALB2 as a candidate melanoma susceptibility genePancreatic ductal adenocarcinoma: risk factors, screening, and early detection.Male fertility defect associated with disrupted BRCA1-PALB2 interaction in micePlasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains.Breast-cancer risk in families with mutations in PALB2Mutation analysis of PALB2 in BRCA1 and BRCA2-negative breast and/or ovarian cancer families from Eastern Ontario, Canada.Gene discovery in familial cancer syndromes by exome sequencing: prospects for the elucidation of familial colorectal cancer type X.Mutation analysis of BRCA1, BRCA2, PALB2 and BRD7 in a hospital-based series of German patients with triple-negative breast cancer.Hereditary ovarian cancer: not only BRCA 1 and 2 genes.A unified analytic framework for prioritization of non-coding variants of uncertain significance in heritable breast and ovarian cancer.Contribution of the PALB2 c.2323C>T [p.Q775X] founder mutation in well-defined breast and/or ovarian cancer families and unselected ovarian cancer cases of French Canadian descent.Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination.Analysis of PALB2 gene in BRCA1/BRCA2 negative Spanish hereditary breast/ovarian cancer families with pancreatic cancer casesSynthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations.Association of PALB2 sequence variants with the risk of familial and early-onset breast cancer in a South-American populationPathogenic PALB2 mutation in metastatic pancreatic adenocarcinoma and neuroendocrine tumour: A case report.PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and functionRoutine testing for PALB2 mutations in familial pancreatic cancer families and breast cancer families with pancreatic cancer is not indicatedPrevalence of PALB2 mutations in Australian familial breast cancer cases and controlsResponse to DNA damage of CHEK2 missense mutations in familial breast cancer.Clinical Application of Multigene Panels: Challenges of Next-Generation Counseling and Cancer Risk Management.PALB2 mutations in breast cancer patients from a multi-ethnic region in northwest China.Ovarian cancer: can proteomics give new insights for therapy and diagnosis?Genome-wide sequencing to identify the cause of hereditary cancer syndromes: with examples from familial pancreatic cancer.Genetic evaluation and testing for hereditary forms of cancer in the era of next-generation sequencing.Prevalence of PALB2 mutations in Australasian multiple-case breast cancer familiesInherited and acquired alterations in development of breast cancer.Tumour morphology predicts PALB2 germline mutation status.PALB2 and breast cancer: ready for clinical translation!Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer.
P2860
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P2860
Contribution of inherited mutations in the BRCA2-interacting protein PALB2 to familial breast cancer.
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Contribution of inherited muta ...... LB2 to familial breast cancer.
@ast
Contribution of inherited muta ...... LB2 to familial breast cancer.
@en
type
label
Contribution of inherited muta ...... LB2 to familial breast cancer.
@ast
Contribution of inherited muta ...... LB2 to familial breast cancer.
@en
prefLabel
Contribution of inherited muta ...... LB2 to familial breast cancer.
@ast
Contribution of inherited muta ...... LB2 to familial breast cancer.
@en
P2093
P2860
P50
P1433
P1476
Contribution of inherited muta ...... LB2 to familial breast cancer.
@en
P2093
Jessica B Mandell
Ming K Lee
Silvia Casadei
Sunday Stray
P2860
P304
P356
10.1158/0008-5472.CAN-10-3958
P407
P577
2011-02-01T00:00:00Z