PTEN mutations as a cause of constitutive insulin sensitivity and obesity. - Wikidata - awgldk - TriplyDB

PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

http://www.wikidata.org/entity/Q33811688

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Phosphatase and Tensin Homologue: Novel Regulation by Developmental Signaling Balancing Proliferation and Connectivity in PTEN-associated Autism Spectrum Disorder Insulin receptor signaling in normal and insulin-resistant states Mourning Dr. Alfred G. Knudson: the two-hit hypothesis, tumor suppressor genes, and the tuberous sclerosis complex Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance Questioning the preclinical paradigm: natural, extreme biology as an alternative discovery platform Human genetics as a model for target validation: finding new therapies for diabetes.Bridging the gap between genetic associations and molecular mechanisms for type 2 diabetes.MicroRNA-486-dependent modulation of DOCK3/PTEN/AKT signaling pathways improves muscular dystrophy-associated symptoms Metabolic regulation by protein tyrosine phosphatases.Targeted deletion of PTEN in cardiomyocytes renders cardiac contractile dysfunction through interruption of Pink1-AMPK signaling and autophagy Whole Genome Association Studies of Residual Feed Intake and Related Traits in the Pig.PTEN: Multiple Functions in Human Malignant Tumors New genetic loci link adipose and insulin biology to body fat distribution.Sex differences in skeletal muscle phosphatase and tensin homolog deleted on chromosome 10 (PTEN) levels: a cross-sectional study.Role of PTEN in TNFα induced insulin resistance Adipose tissue plasticity from WAT to BAT and in between.Detecting Germline PTEN Mutations Among At-Risk Patients With Cancer: An Age- and Sex-Specific Cost-Effectiveness Analysis Detailed phenotyping identifies genes with pleiotropic effects on body composition.Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis.Role of PTEN in Oxidative Stress and DNA Damage in the Liver of Whole-Body Pten Haplodeficient Mice Mitochondria-related miR-141-3p contributes to mitochondrial dysfunction in HFD-induced obesity by inhibiting PTEN.Growth hormone replacement therapy regulates microRNA-29a and targets involved in insulin resistance Greater insulin-mediated Akt phosphorylation concomitant with heterogeneous effects on phosphorylation of Akt substrates in soleus of calorie-restricted rats Circulating micrornas associated with glycemic impairment and progression in Asian Indians SHORT syndrome with partial lipodystrophy due to impaired phosphatidylinositol 3 kinase signaling.SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis.High fat diet-induced TGF-β/Gbb signaling provokes insulin resistance through the tribbles expression.A new mathematical approach for qualitative modeling of the insulin-TOR-MAPK network.TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice.PTEN in cancer, metabolism, and aging.Genome-wide interrogation reveals hundreds of long intergenic noncoding RNAs that associate with cardiometabolic traits.Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue.Regeneration of diabetic axons is enhanced by selective knockdown of the PTEN gene.Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation.The genetics of type 2 diabetes and its clinical relevance.Novel therapeutics for type 2 diabetes: insulin resistance.Insulin supersensitivity and normoinsulinaemic hypoglycaemia in uncontrolled type 2 diabetes mellitus: clinical usefulness of 3 h assessment in the 75 g oral glucose tolerance test.

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PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

http://www.wikidata.org/entity/Q33811688

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2012 nî lūn-bûn

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2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

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PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

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PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

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PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

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PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

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PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

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The New England Journal of Medicine

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PTEN mutations as a cause of constitutive insulin sensitivity and obesity

@en

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Aparna Pal

http://www.w3.org/2001/XMLSchema#string

Helen Linden

http://www.w3.org/2001/XMLSchema#string

Lisa Walker

http://www.w3.org/2001/XMLSchema#string

Nicola S Cooper

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Simon A Rudge

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Thomas M Barber

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P2860

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Correct homeostasis model assessment (HOMA) evaluation uses the computer program

Multiple loci identified in a genome-wide association study of prostate cancer

The metabolic syndrome--a new worldwide definition

Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue

Muscle-specific Pten deletion protects against insulin resistance and diabetes

Glucose clamp technique: a method for quantifying insulin secretion and resistance.

Adiponectin: a link between obesity and cancer.

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1002-1011

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scholarly article

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10.1056/NEJMOA1113966

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11

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367

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Michael Wakelam

Martijn van de Bunt

Jonathan Cummings Levy

Katherine L Lachlan

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2012-09-01T00:00:00Z

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22970944

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4072504

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