Predicting drug-induced slowing of conduction and pro-arrhythmia: identifying the 'bad' sodium current blockers.
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Engineered heart slices for electrophysiological and contractile studies.Parameterization for In-Silico Modeling of Ion Channel Interactions with DrugsA computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythmsFatalities temporally associated with the ingestion of ibogaine.Pharmacology and Toxicology of Nav1.5-Class 1 anti-arrhythmic drugs.Cardiac Safety Implications of hNav1.5 Blockade and a Framework for Pre-Clinical Evaluation.Does terfenadine-induced ventricular tachycardia/fibrillation directly relate to its QT prolongation and Torsades de Pointes?Role of mixed ion channel effects in the cardiovascular safety assessment of the novel anti-MRSA fluoroquinolone JNJ-Q2Rate-dependent activation failure in isolated cardiac cells and tissue due to Na+ channel block.Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentialsQT interval prolongation and torsade de pointes: Synergistic effect of flecainide and H1 receptor antagonists.Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening.Late sodium current inhibition in acquired and inherited ventricular (dys)function and arrhythmias.The 'overly-sensitive' heart: sodium channel block and QRS interval prolongation.Role of abnormal repolarization in the mechanism of cardiac arrhythmia.Evaluation of Index of Cardio-Electrophysiological Balance (iCEB) as a New Biomarker for the Identification of Patients at Increased Arrhythmic Risk.Synergistic Effect of Dofetilide and Mexiletine on Prevention of Atrial Fibrillation.Investigation of connexin 43 uncoupling and prolongation of the cardiac QRS complex in preclinical and marketed drugs.The novel late Na+ current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations2011 Annual Meeting of the Safety Pharmacology Society: an overview.Shensong Yangxin (SSYX) ameliorates disordered excitation transmission by suppressing cardiac collagen hyperplasia in rabbits with chronic myocardial infarction.Effects of HIV Protease Inhibitors on Cardiac Conduction Velocity in Unselected HIV-Infected Patients
P2860
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P2860
Predicting drug-induced slowing of conduction and pro-arrhythmia: identifying the 'bad' sodium current blockers.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Predicting drug-induced slowin ...... 'bad' sodium current blockers.
@ast
Predicting drug-induced slowin ...... 'bad' sodium current blockers.
@en
type
label
Predicting drug-induced slowin ...... 'bad' sodium current blockers.
@ast
Predicting drug-induced slowin ...... 'bad' sodium current blockers.
@en
prefLabel
Predicting drug-induced slowin ...... 'bad' sodium current blockers.
@ast
Predicting drug-induced slowin ...... 'bad' sodium current blockers.
@en
P2093
P2860
P1476
Predicting drug-induced slowin ...... 'bad' sodium current blockers.
@en
P2093
David J Gallacher
Eddy Vlaminckx
Gan-Xin Yan
Hua Rong Lu
Jutta Rohrbacher
Karel Van Ammel
P2860
P356
10.1111/J.1476-5381.2010.00646.X
P407
P577
2010-03-22T00:00:00Z