Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation
about
Novel Immune Check-Point Regulators in Tolerance MaintenanceCo-Stimulatory Blockade of the CD28/CD80-86/CTLA-4 Balance in Transplantation: Impact on Memory T Cells?Update on CD40 and CD154 blockade in transplant modelsCD28 co-stimulation in T-cell homeostasis: a recent perspectiveTargeting CD28, CTLA-4 and PD-L1 costimulation differentially controls immune synapses and function of human regulatory and conventional T-cellsReconsidering the detection of tolerance to individualize immunosuppression minimization and to improve long-term kidney graft outcomesSuppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects.Advantages of Papio anubis for preclinical testing of immunotoxicity of candidate therapeutic antagonist antibodies targeting CD28IL-2-Mediated In Vivo Expansion of Regulatory T Cells Combined with CD154-CD40 Co-Stimulation Blockade but Not CTLA-4 Ig Prolongs Allograft Survival in Naive and Sensitized MiceCostimulatory pathways in transplantation.Immunotherapeutic strategies in autoimmune uveitisIndoleamine 2,3 dioxygenase and metabolic control of immune responses.Roles of CD28, CTLA4, and inducible costimulator in acute graft-versus-host disease in mice.The role of coinhibitory signaling pathways in transplantation and toleranceCD28 ligation increases macrophage suppression of T-cell proliferation.Novel CD28 antagonist mPEG PV1-Fab' mitigates experimental autoimmune uveitis by suppressing CD4+ T lymphocyte activation and IFN-γ production.Antagonist properties of monoclonal antibodies targeting human CD28: role of valency and the heavy-chain constant domainPre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model.Primate models in organ transplantationCostimulation Blockade in Kidney Transplantation: An Update2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses.Blocking costimulatory pathways: prospects for inducing transplantation tolerance.Alternatives to calcineurin inhibition in renal transplantation: belatacept, the first co-stimulation blocker.CD4+ regulatory T cells in solid organ transplantation.A more selective costimulatory blockade of the CD28-B7 pathway.Immunobiology of transplantation: impact on targets for large and small molecules.Belatacept: from rational design to clinical application.Rejection and regulation: a tight balance.CD28-specific immunomodulating antibodies: what can be learned from experimental models?The role of costimulatory molecules in directing the functional differentiation of alloreactive T helper cells.The Role of the PI3K Signaling Pathway in CD4(+) T Cell Differentiation and Function.Translating tolerogenic therapies to the clinic - where do we stand?Belatacept: a new era of immunosuppression?Prognostic significance of graft Foxp3 expression in renal transplant recipients: a critical review and attempt to reconcile discrepancies.T-cell co-stimulatory blockade in transplantation: two steps forward one step back!Targeting co-stimulatory pathways: transplantation and autoimmunity.Costimulatory pathways in kidney transplantation: pathogenetic role, clinical significance and new therapeutic opportunities.T-cell costimulatory blockade in organ transplantation.Targeting CD28 to prevent transplant rejection.Biomarkers and possible mechanisms of operational tolerance in kidney transplant patients.
P2860
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P2860
Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Inducing CTLA-4-dependent immu ...... cells in organ transplantation
@ast
Inducing CTLA-4-dependent immu ...... cells in organ transplantation
@en
type
label
Inducing CTLA-4-dependent immu ...... cells in organ transplantation
@ast
Inducing CTLA-4-dependent immu ...... cells in organ transplantation
@en
prefLabel
Inducing CTLA-4-dependent immu ...... cells in organ transplantation
@ast
Inducing CTLA-4-dependent immu ...... cells in organ transplantation
@en
P2093
P2860
P1476
Inducing CTLA-4-dependent immu ...... cells in organ transplantation
@en
P2093
Agnes M Azimzadeh
Bao Nguyen
Bernard Martinet
Bernard Vanhove
Caroline Mary
Emma Allain-Launay
Flora Coulon
Georges Karam
Gilles Blancho
Guosheng Wu
P2860
P304
P356
10.1126/SCITRANSLMED.3000116
P407
P577
2010-02-01T00:00:00Z