SIMPLE/LITAF expression induces the translocation of the ubiquitin ligase itch towards the lysosomal compartments.
about
Charcot-Marie-Tooth disease and intracellular trafficThe Charcot Marie Tooth disease protein LITAF is a zinc-binding monotopic membrane protein.Accumulation of endogenous LITAF in aggresomesLITAF mutations associated with Charcot-Marie-Tooth disease 1C show mislocalization from the late endosome/lysosome to the mitochondria.Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein.The topology, structure and PE interaction of LITAF underpin a Charcot-Marie-Tooth disease type 1C.LPS-induced TNF-α factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver diseaseMutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes.The E3 ligase Itch in immune regulation and beyond.Cellular LITAF interacts with frog virus 3 75L protein and alters its subcellular localization.SIMPLE binds specifically to PI4P through SIMPLE-like domain and participates in protein trafficking in the trans-Golgi network and/or recycling endosomes.
P2860
Q26824841-375BA476-C250-449D-BDF1-1D0F1C60611FQ29977769-D96DEFB1-BA86-413B-9DFC-383AA5A64F66Q34140309-82F04EAE-6601-4BD3-84A6-9DE47679BCEAQ35212568-04F8997C-3384-48F3-91CE-BC0793AA4BE3Q35764200-CE3C2F64-2286-4156-B677-9CEADD25B9BEQ36215275-ABAA07D7-528E-4443-8412-7557E48CCA6FQ36561514-E5228DFA-6A8B-4CEE-BBAE-FA6217BF2D90Q36887372-936A912F-876A-4FF4-848B-DBC9FAFF4C45Q38530613-E8567883-7D54-475A-9231-CDB6717C0599Q39253630-07965857-9226-4132-9693-84B2D75B4610Q55514505-44C17CA1-AA75-415D-B40B-79C45FE4414B
P2860
SIMPLE/LITAF expression induces the translocation of the ubiquitin ligase itch towards the lysosomal compartments.
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
SIMPLE/LITAF expression induce ...... ds the lysosomal compartments.
@ast
SIMPLE/LITAF expression induce ...... ds the lysosomal compartments.
@en
type
label
SIMPLE/LITAF expression induce ...... ds the lysosomal compartments.
@ast
SIMPLE/LITAF expression induce ...... ds the lysosomal compartments.
@en
prefLabel
SIMPLE/LITAF expression induce ...... ds the lysosomal compartments.
@ast
SIMPLE/LITAF expression induce ...... ds the lysosomal compartments.
@en
P2093
P2860
P1433
P1476
SIMPLE/LITAF expression induce ...... rds the lysosomal compartments
@en
P2093
Craig R Brunetti
Guillaume Desrochers
Heather E Eaton
Julie Metcalf
P2860
P304
P356
10.1371/JOURNAL.PONE.0016873
P407
P577
2011-02-04T00:00:00Z