Using photolabile ligands in drug discovery and development.
about
Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin eggPhotoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cellsPolymorphic cytochrome P450 enzymes (CYPs) and their role in personalized therapyDesign and synthesis of novel prostaglandin E2 ethanolamide and glycerol ester probes for the putative prostamide receptor(s)Peptidomimetic antibiotics target outer-membrane biogenesis in Pseudomonas aeruginosaPhotoaffinity labeling combined with mass spectrometric approaches as a tool for structural proteomics.Mass spectrometric approaches to study protein structure and interactions in lyophilized powders.Azido push-pull fluorogens photoactivate to produce bright fluorescent labels.Cgamma H2 of Met174 side chain is the site of covalent attachment of a substance P analog photoactivable in position 5.Met174 side chain is the site of photoinsertion of a substance P competitive peptide antagonist photoreactive in position 8.Photoactivatable synthetic Ras proteins: "baits" for the identification of plasma-membrane-bound binding partners of Ras.Molecular characterization of the human Calpha-formylglycine-generating enzyme.Synthesis and two-photon photolysis of 6-(ortho-nitroveratryl)-caged IP3 in living cells.Identifying an interaction site between MutH and the C-terminal domain of MutL by crosslinking, affinity purification, chemical coding and mass spectrometry.In situ assembly of macromolecular complexes triggered by lightNicotinic Acid Adenine Dinucleotide 2'-Phosphate (NAADP) Binding Proteins in T-Lymphocytes.Light-mediated remote control of signaling pathways.Azido-iodo-N-benzyl derivatives of threo-methylphenidate (Ritalin, Concerta): Rational design, synthesis, pharmacological evaluation, and dopamine transporter photoaffinity labeling.Active/inactive dual-probe system for selective photoaffinity labeling of small molecule-binding proteins.Selective fluorescence detection of small-molecule-binding proteins by using a dual photoaffinity labeling system.Dual wavelength photoactivation of cAMP- and cGMP-dependent protein kinase signaling pathways.Distinct metabolites for photoreactive L-phenylalanine derivatives in Klebsiella sp. CK6 isolated from rhizosphere of a wild dipterocarp sapling.Isoelectric focusing technology quantifies protein signaling in 25 cells.Moleular models for cholecystokinin-A receptor.An in vivo photo-cross-linking approach reveals a homodimerization domain of Aha1 in S. cerevisiaeScreening and synthesis: high throughput technologies applied to parasitology.A Photo-Crosslinkable Biotin Derivative of the Phosphoantigen (E)-4-Hydroxy-3-Methylbut-2-Enyl Diphosphate (HMBPP) Activates Vγ9Vδ2 T Cells and Binds to the HMBPP Site of BTN3A1.A designed inhibitor of a CLC antiporter blocks function through a unique binding mode.Metabolites involved in plant movement and 'memory': nyctinasty of legumes and trap movement in the Venus flytrap.Photoremovable protecting groups in chemistry and biology: reaction mechanisms and efficacy.Photochemical control of biological processes.Synthesis of photoactivatable analogues of lysophosphatidic acid and covalent labeling of plasma proteins.Illuminating the chemistry of life: design, synthesis, and applications of "caged" and related photoresponsive compounds.Design Considerations for RNA Spherical Nucleic Acids (SNAs).Radiation- and photo-induced activation of 5-fluorouracil prodrugs as a strategy for the selective treatment of solid tumors.Nanoengineering ion channels for optical control.Traceless cross-linker for photocleavable bioconjugation.Synthesis and evaluation of photoreactive tetrazole amino acids.The Transformer database: biotransformation of xenobiotics.Determining target engagement in living systems
P2860
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P2860
Using photolabile ligands in drug discovery and development.
description
2000 nî lūn-bûn
@nan
2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Using photolabile ligands in drug discovery and development.
@ast
Using photolabile ligands in drug discovery and development.
@en
type
label
Using photolabile ligands in drug discovery and development.
@ast
Using photolabile ligands in drug discovery and development.
@en
prefLabel
Using photolabile ligands in drug discovery and development.
@ast
Using photolabile ligands in drug discovery and development.
@en
P1476
Using photolabile ligands in drug discovery and development
@en
P2093
Prestwich GD
P356
10.1016/S0167-7799(99)01402-X
P577
2000-02-01T00:00:00Z