Development of an intergenotypic hepatitis C virus (HCV) cell culture method to assess antiviral susceptibilities and resistance development of HCV NS3 protease genes from HCV genotypes 1 to 6

Development of an intergenotypic hepatitis C virus (HCV) cell culture method to assess antiviral susceptibilities and resistance development of HCV NS3 protease genes from HCV genotypes 1 to 6

Item
http://www.wikidata.org/entity/Q33826766
Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains.Substitutions at NS3 Residue 155, 156, or 168 of Hepatitis C Virus Genotypes 2 to 6 Induce Complex Patterns of Protease Inhibitor ResistanceHighly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system.Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle.Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor.Identification of alpha interferon-induced envelope mutations of hepatitis C virus in vitro associated with increased viral fitness and interferon resistance.A novel strategy to develop a robust infectious hepatitis C virus cell culture system directly from a clinical isolateUnderstanding the hepatitis C virus life cycle paves the way for highly effective therapies.PCR-based in vitro synthesis of hepatitis C virus NS3 protease for rapid phenotypic resistance testing of protease inhibitors.Genotype differences in susceptibility and resistance development of hepatitis C virus to protease inhibitors telaprevir (VX-950) and danoprevir (ITMN-191).Selection of clinically relevant protease inhibitor-resistant viruses using the genotype 2a hepatitis C virus infection system.Flexible and rapid construction of viral chimeras applied to hepatitis C virus.Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice.
P2860

Development of an intergenotypic hepatitis C virus (HCV) cell culture method to assess antiviral susceptibilities and resistance development of HCV NS3 protease genes from HCV genotypes 1 to 6

Item
http://www.wikidata.org/entity/Q33826766
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Development of an intergenotyp ...... enes from HCV genotypes 1 to 6
@ast
Development of an intergenotyp ...... enes from HCV genotypes 1 to 6
@en
type
label
Development of an intergenotyp ...... enes from HCV genotypes 1 to 6
@ast
Development of an intergenotyp ...... enes from HCV genotypes 1 to 6
@en
prefLabel
Development of an intergenotyp ...... enes from HCV genotypes 1 to 6
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Development of an intergenotyp ...... enes from HCV genotypes 1 to 6
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P932
P356
P1433
P1476
Development of an intergenotyp ...... enes from HCV genotypes 1 to 6
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P932