Hsp90/Cdc37 chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A - Wikidata - awgldk - TriplyDB

Hsp90/Cdc37 chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A

Hsp90/Cdc37 chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A

http://www.wikidata.org/entity/Q33826976

about

Ashwagandha derived withanone targets TPX2-Aurora A complex: computational and experimental evidence to its anticancer activity In vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index.Mechanistic elucidation of the antitumor properties of withaferin a in breast cancer.Non-nucleosidic inhibition of Herpes simplex virus DNA polymerase: mechanistic insights into the anti-herpetic mode of action of herbal drug withaferin A Withanolides-induced breast cancer cell death is correlated with their ability to inhibit heat protein 90 Blocking protein kinase C signaling pathway: mechanistic insights into the anti-leishmanial activity of prospective herbal drugs from Withania somnifera.Regulation of the mammalian heat shock factor 1.A study of the mechanism of the chaperone-like function of an scFv of human creatine kinase by computer simulation Oxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation.Could the FDA-approved anti-HIV PR inhibitors be promising anticancer agents? An answer from enhanced docking approach and molecular dynamics analyses Novel HSP90 inhibitors effectively target functions of thyroid cancer stem cell preventing migration and invasion Withania somnifera Induces Cytotoxic and Cytostatic Effects on Human T Leukemia Cells.In Silico Analysis of Microarray-Based Gene Expression Profiles Predicts Tumor Cell Response to Withanolides Biotechnological interventions in Withania somnifera (L.) Dunal.AshwaMAX and Withaferin A inhibits gliomas in cellular and murine orthotopic models Cinnamaldehyde and eugenol change the expression folds of AKT1 and DKC1 genes and decrease the telomere length of human adipose-derived stem cells (hASCs): An experimental and in silico study.Natural Withanolides in the Treatment of Chronic Diseases.Withaferin A and its potential role in glioblastoma (GBM).Molecular insights into cancer therapeutic effects of the dietary medicinal phytochemical withaferin A.Promising Anti-influenza Properties of Active Constituent of Withania somnifera Ayurvedic Herb in Targeting Neuraminidase of H1N1 Influenza: Computational Study.Interactome analysis of transforming growth factor-β-activated kinase 1 in Helicobacter pylori-infected cells revealed novel regulators tripartite motif 28 and CDC37.Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery.Computational evidence to inhibition of human acetyl cholinesterase by withanolide a for Alzheimer treatment.

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P2860

Hsp90/Cdc37 chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A

http://www.wikidata.org/entity/Q33826976

description

2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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Hsp90/Cdc37 chaperone/co-chape ...... on of herbal drug Withaferin A

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BMC Bioinformatics

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Hsp90/Cdc37 chaperone/co-chape ...... on of herbal drug Withaferin A

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Abhinav Grover

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Ashutosh Shandilya

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Divya Bhasme

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Durai Sundar

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Piyush Pratik

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Vibhuti Agrawal

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Virendra S Bisaria

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P2860

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains

The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)

The human Cdc37.Hsp90 complex studied by heteronuclear NMR spectroscopy

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone.

Differential expression of heat shock proteins in pancreatic carcinoma

Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol

p50(cdc37) binds directly to the catalytic domain of Raf as well as to a site on hsp90 that is topologically adjacent to the tetratricopeptide repeat binding site

A proteomic snapshot of the human heat shock protein 90 interactome

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1471-2105-12-s1-s30

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S30

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scholarly article

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10.1186/1471-2105-12-S1-S30

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12 Suppl 1

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2011-02-15T00:00:00Z

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1028209298

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21342561

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molecular chaperones

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3044286

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