The C-terminus of Toxoplasma RON2 provides the crucial link between AMA1 and the host-associated invasion complex
about
The cellular and molecular basis for malaria parasite invasion of the human red blood cellConditional expression of apical membrane antigen 1 in Plasmodium falciparum shows it is required for erythrocyte invasion by merozoitesSpatial localisation of actin filaments across developmental stages of the malaria parasiteHost cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptideBabesia divergensandNeospora caninumapical membrane antigen 1 structures reveal selectivity and plasticity in apicomplexan parasite host cell invasionToxoplasma gondii Sporozoites Invade Host Cells Using Two Novel Paralogues of RON2 and AMA1Structural and Functional Insights into the Malaria Parasite Moving Junction ComplexApical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasion.RON12, a novel Plasmodium-specific rhoptry neck protein important for parasite proliferation.Subcompartmentalisation of proteins in the rhoptries correlates with ordered events of erythrocyte invasion by the blood stage malaria parasiteAMA1 and MAEBL are important for Plasmodium falciparum sporozoite infection of the liverBinding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion.Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria.Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodiesTranscriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.Subversion of host cellular functions by the apicomplexan parasites.Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditionsProduction, characterization and applications for Toxoplasma gondii-specific polyclonal chicken egg yolk immunoglobulins.Toxoplasma co-opts host cells it does not invadeMalaria biology and disease pathogenesis: insights for new treatments.Global proteomic analysis of the oocyst/sporozoite of Toxoplasma gondii reveals commitment to a host-independent lifestyleProtective immunity induced by peptides of AMA1, RON2 and RON4 containing T-and B-cell epitopes via an intranasal route against toxoplasmosis in mice.Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.RON5 is critical for organization and function of the Toxoplasma moving junction complexHost cell invasion by apicomplexan parasites: the junction conundrumThe shear stress of host cell invasion: exploring the role of biomolecular complexesComputational and biophysical approaches to protein-protein interaction inhibition of Plasmodium falciparum AMA1/RON2 complex.An Extended Surface Loop on Toxoplasma gondii Apical Membrane Antigen 1 (AMA1) Governs Ligand Binding SelectivityThe moving junction, a key portal to host cell invasion by apicomplexan parasites.An in vitro model of intestinal infection reveals a developmentally regulated transcriptome of Toxoplasma sporozoites and a NF-κB-like signature in infected host cells.Dissecting the interface between apicomplexan parasite and host cell: Insights from a divergent AMA-RON2 pairLocalisation-based imaging of malarial antigens during erythrocyte entry reaffirms a role for AMA1 but not MTRAP in invasionIdentification and Characterization of the Rhoptry Neck Protein 2 in Babesia divergens and B. microti.Concepts and mechanisms: crossing host barriers.Not a Simple Tether: Binding of Toxoplasma gondii AMA1 to RON2 during Invasion Protects AMA1 from Rhomboid-Mediated Cleavage and Leads to Dephosphorylation of Its Cytosolic TailImmunization with apical membrane antigen 1 confers sterile infection-blocking immunity against Plasmodium sporozoite challenge in a rodent model.Invasion factors are coupled to key signalling events leading to the establishment of infection in apicomplexan parasites.The moving junction of apicomplexan parasites: a key structure for invasion.Focus on the ringleader: the role of AMA1 in apicomplexan invasion and replication.Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine.
P2860
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P2860
The C-terminus of Toxoplasma RON2 provides the crucial link between AMA1 and the host-associated invasion complex
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The C-terminus of Toxoplasma R ...... st-associated invasion complex
@ast
The C-terminus of Toxoplasma R ...... st-associated invasion complex
@en
type
label
The C-terminus of Toxoplasma R ...... st-associated invasion complex
@ast
The C-terminus of Toxoplasma R ...... st-associated invasion complex
@en
prefLabel
The C-terminus of Toxoplasma R ...... st-associated invasion complex
@ast
The C-terminus of Toxoplasma R ...... st-associated invasion complex
@en
P2860
P1433
P1476
The C-terminus of Toxoplasma R ...... st-associated invasion complex
@en
P2093
Jessica S Tyler
John C Boothroyd
P2860
P304
P356
10.1371/JOURNAL.PPAT.1001282
P577
2011-02-10T00:00:00Z